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1
N-formimidoyl thienamycin (MK0787): in vitro study.N-甲酰亚胺基硫霉素（MK0787）：体外研究。
Antimicrob Agents Chemother. 1981 Jan;19(1):201-4. doi: 10.1128/AAC.19.1.201.
2
In vitro activity of N-formimidoyl thienamycin (MK0787), a crystalline derivative of thienamycin.硫霉素的结晶衍生物N-甲脒基硫霉素（MK0787）的体外活性
Antimicrob Agents Chemother. 1980 Oct;18(4):557-61. doi: 10.1128/AAC.18.4.557.
3
In vitro activity of N-formimidoyl thienamycin in comparison with cefotaxime, moxalactam, and ceftazidime.与头孢噻肟、拉氧头孢和头孢他啶相比，N-甲酰亚胺硫霉素的体外活性。
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A comparison of the antibacterial activities of N-formimidoyl thienamycin (MK0787) with those of other recently developed beta-lactam derivatives.N-甲酰亚胺基硫霉素（MK0787）与其他近期研发的β-内酰胺衍生物抗菌活性的比较。
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5
Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics.一种新型稳定化硫霉素（N-甲脒基硫霉素）与其他抗生素相比的抗菌活性。
Antimicrob Agents Chemother. 1980 Jun;17(6):912-7. doi: 10.1128/AAC.17.6.912.
6
MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.MK0787（N-亚胺甲酰硫霉素）：体内外活性评估
Antimicrob Agents Chemother. 1980 Jun;17(6):993-1000. doi: 10.1128/AAC.17.6.993.
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Influence of inoculum size on activity of cefoperazone, cefotaxime, moxalactam, piperacillin, and N-formimidoyl thienamycin (MK0787) against Pseudomonas aeruginosa.接种量对头孢哌酮、头孢噻肟、拉氧头孢、哌拉西林及N-甲酰亚胺硫霉素（MK0787）抗铜绿假单胞菌活性的影响。
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In vitro evaluation of N-formimidoyl thienamycin (MK0787) combined with amikacin against gram-negative bacilli and Staphylococcus aureus.N-甲酰亚胺硫霉素（MK0787）联合阿米卡星对革兰氏阴性杆菌和金黄色葡萄球菌的体外评价
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In vitro activity of N-formimidoyl thienamycin (MK0787).N-甲酰亚胺基硫霉素（MK0787）的体外活性
Antimicrob Agents Chemother. 1980 Oct;18(4):642-4. doi: 10.1128/AAC.18.4.642.
10
In vitro activity of N-formimidoyl thienamycin (MK0787) against resistant strains of Pseudomonas aeruginosa, Staphylococcus epidermidis, Serratia marcescens, and Enterococcus spp.N-甲脒基硫霉素（MK0787）对铜绿假单胞菌、表皮葡萄球菌、粘质沙雷氏菌和肠球菌属耐药菌株的体外活性
Antimicrob Agents Chemother. 1981 Jan;19(1):114-6. doi: 10.1128/AAC.19.1.114.

引用本文的文献

1
Comparative activities of 13 beta-lactam antibiotics.13种β-内酰胺类抗生素的比较活性
Antimicrob Agents Chemother. 1982 Jun;21(6):925-34. doi: 10.1128/AAC.21.6.925.
2
Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis.N-甲酰亚胺硫霉素在实验性大肠杆菌脑膜炎中的药代动力学及细菌学疗效
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Antimicrob Agents Chemother. 1982 Jun;21(6):1016-22. doi: 10.1128/AAC.21.6.1016.
4
[N-formimidoyl-thienamycin: in vitro activity in bacteria with resistance to beta-lactam antibiotics or gentamicin].[N-甲脒基硫霉素：对β-内酰胺类抗生素或庆大霉素耐药细菌的体外活性]
Infection. 1982 Nov-Dec;10(6):361-70. doi: 10.1007/BF01642300.
5
Superior activity of N-formimidoyl thienamycin against gentamicin-resistant Pseudomonas aeruginosa.N-甲酰亚胺硫霉素对庆大霉素耐药铜绿假单胞菌的活性更强。
Antimicrob Agents Chemother. 1981 Nov;20(5):702-4. doi: 10.1128/AAC.20.5.702.
6
The in vitro activity of N-formimidoyl thienamycin compared with other broad-spectrum cephalosporins and with clindamycin and metronidazole.与其他广谱头孢菌素、克林霉素和甲硝唑相比，N-甲酰亚胺基硫霉素的体外活性。
Infection. 1983 Jul-Aug;11(4):219-26. doi: 10.1007/BF01641202.
7
In vitro activity of imipenem--a review.亚胺培南的体外活性——综述
Eur J Clin Microbiol. 1984 Oct;3(5):456-62. doi: 10.1007/BF02017375.
8
In vitro activity of N-formimidoyl-thienamycin in comparison to that of moxalactam and cefotaxime against gentamicin-resistant gram-negative bacteria.与羟羧氧酰胺菌素和头孢噻肟相比，N-甲脒硫霉素对庆大霉素耐药革兰氏阴性菌的体外活性
Eur J Clin Microbiol. 1982 Feb;1(1):49-51. doi: 10.1007/BF02014140.
9
Comparative in vitro activities of N-formimidoyl thienamycin and moxalactam against nonfermentative aerobic gram-negative rods.N-甲脒硫霉素和羟羧氧酰胺菌素对非发酵需氧革兰氏阴性杆菌的体外比较活性
Antimicrob Agents Chemother. 1982 Apr;21(4):673-5. doi: 10.1128/AAC.21.4.673.

本文引用的文献

1
MK0787 (N-formimidoyl thienamycin): evaluation of in vitro and in vivo activities.MK0787（N-亚胺甲酰硫霉素）：体内外活性评估
Antimicrob Agents Chemother. 1980 Jun;17(6):993-1000. doi: 10.1128/AAC.17.6.993.
2
Antibacterial activities of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics.一种新型稳定化硫霉素（N-甲脒基硫霉素）与其他抗生素相比的抗菌活性。
Antimicrob Agents Chemother. 1980 Jun;17(6):912-7. doi: 10.1128/AAC.17.6.912.
3
Thienamycin, a new beta-lactam antibiotic. I. Discovery, taxonomy, isolation and physical properties.硫霉素，一种新型β-内酰胺抗生素。I. 发现、分类学、分离及物理性质。
J Antibiot (Tokyo). 1979 Jan;32(1):1-12. doi: 10.7164/antibiotics.32.1.
4
In vitro activity of thienamycin.硫霉素的体外活性。
Antimicrob Agents Chemother. 1978 Sep;14(3):436-8. doi: 10.1128/AAC.14.3.436.
5
Thienamycin: new beta-lactam antibiotic with potent broad-spectrum activity.硫霉素：具有强大广谱活性的新型β-内酰胺抗生素。
Antimicrob Agents Chemother. 1979 Apr;15(4):518-21. doi: 10.1128/AAC.15.4.518.

N-甲酰亚胺基硫霉素（MK0787）：体外研究。

N-formimidoyl thienamycin (MK0787): in vitro study.

作者信息

Shadomy S, May R S

出版信息

Antimicrob Agents Chemother. 1981 Jan;19(1):201-4. doi: 10.1128/AAC.19.1.201.

DOI:10.1128/AAC.19.1.201
PMID:6941741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC181385/
Abstract

N-Formimidoyl thienamycin (MK0787) was compared in vitro with three other beta-lactam and two aminoglycoside antibiotics. It was second in activity only to cefotaxime against members of the Enterobacteriaceae and to amikacin against Pseudomonas species. It was the most active antibiotic against Staphylococcus aureus. Resistance (minimal inhibitory concentration, greater than 128 microgram/ml) to N-formimidoyl thienamycin was not observed.

摘要

将N-甲脒硫霉素（MK0787）与其他三种β-内酰胺类抗生素和两种氨基糖苷类抗生素进行了体外比较。在抗肠杆菌科细菌方面，其活性仅次于头孢噻肟；在抗假单胞菌属方面，仅次于阿米卡星。它是对金黄色葡萄球菌活性最强的抗生素。未观察到对N-甲脒硫霉素的耐药性（最低抑菌浓度大于128微克/毫升）。