泼尼松和硫唑嘌呤治疗口腔糜烂性疾病患者

Prednisone and azathioprine in the treatment of patient with vesiculoerosive oral diseases.

作者信息

Lozada F

出版信息

Oral Surg Oral Med Oral Pathol. 1981 Sep;52(3):257-63. doi: 10.1016/0030-4220(81)90258-9.

Abstract

Systemic corticosteroids offer the most effective means of treating patients with symptomatic oral vesiculoerosive diseases. However, underlying systemic diseases and adverse side effects limit their use at clinically therapeutic dosages. The purpose of this open clinical trial was to assess the synergistic effect of azathioprine with prednisone, comparing clinical benefits with side effects. Twelve patients were studied. The minimum effective dose of prednisone when azathioprine was never more than 25 mg. daily and ranged as low as 5 mg. daily. This study indicated that azathioprine effectively enhanced corticosteroid activity, allowing lower doses of prednisone with satisfactory clinical efficacy and a marked reduction in side effects.

摘要

全身性皮质类固醇是治疗有症状的口腔水疱糜烂性疾病患者最有效的方法。然而，潜在的全身性疾病和不良副作用限制了它们在临床治疗剂量下的使用。这项开放性临床试验的目的是评估硫唑嘌呤与泼尼松的协同作用，比较临床益处和副作用。对12名患者进行了研究。当硫唑嘌呤每日用量从不超过25毫克且低至每日5毫克时，泼尼松的最低有效剂量。这项研究表明，硫唑嘌呤有效地增强了皮质类固醇的活性，允许使用较低剂量的泼尼松，具有令人满意的临床疗效且副作用明显减少。