与骨肉瘤体液免疫相关的Gm基因座杂合性。
Heterozygosity at Gm loci associated with humoral immunity to osteosarcoma.
作者信息
Pandey J P, Shannon B T, Tsang K Y, Fudenberg H H, Camblin J G
出版信息
J Exp Med. 1982 Apr 1;155(4):1228-32. doi: 10.1084/jem.155.4.1228.
Abstract
Serum samples from 50 Caucasian patients with osteosarcoma were tested for the presence of antibodies to osteosarcoma-associated antigens (OSAA) and typed for nine Gm markers. A highly significant association was found between Gm 3;5,13,14 and unresponsiveness to OSAA, and between 1,3,17;5,13,14,21 and responsiveness to OSAA. These results suggest the existence of complementary immune response genes which in the heterozygous condition permit a response to OSAA.
摘要
对50名患有骨肉瘤的白种人患者的血清样本进行检测，以确定是否存在针对骨肉瘤相关抗原（OSAA）的抗体，并对9种Gm标记进行分型。发现Gm 3;5,13,14与对OSAA无反应之间以及1,3,17;5,13,14,21与对OSAA有反应之间存在高度显著的关联。这些结果表明存在互补免疫反应基因，在杂合状态下允许对OSAA产生反应。
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