恶性黑色素瘤患者的人类白细胞抗原和免疫球蛋白同种异型
HLA antigens and immunoglobulin allotypes in patients with malignant melanoma.
作者信息
Pandey J P, Johnson A H, Fudenberg H H, Amos D B, Gutterman J U, Hersh E M
出版信息
Hum Immunol. 1981 May;2(3):185-90. doi: 10.1016/0198-8859(81)90010-0.
PMID:7263315
Abstract
HLA antigens and Gm, A2m, and Km allotypes were examined in Caucasian patients with malignant melanoma. No significant associations were found for any of the HLA antigens tested. Significant association was found with Gm(2), and the relative risk for individuals with this marker was calculated at 1.9. The data indicate that Caucasians positive for Gm(2) are almost twice as likely to develop malignant melanoma as those without this marker.
摘要
对患有恶性黑色素瘤的白种人患者进行了人类白细胞抗原（HLA）抗原以及Gm、A2m和Km同种异型的检测。在所检测的任何一种HLA抗原中均未发现显著关联。发现与Gm(2)存在显著关联，具有该标记的个体的相对风险经计算为1.9。数据表明，Gm(2)呈阳性的白种人患恶性黑色素瘤的可能性几乎是没有该标记的白种人的两倍。
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