Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 5alpha-cholest-8(14)-en-3beta-ol-15-one in rats and mice.
作者信息
Schroepfer G J, Monger D, Taylor A S, Chamberlain J S, Parish E J, Kisic A, Kandutsch A A
出版信息
Biochem Biophys Res Commun. 1977 Oct 24;78(4):1227-33. doi: 10.1016/0006-291x(77)91424-3.
PMID:921774
Abstract
摘要
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Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 5alpha-cholest-8(14)-en-3beta-ol-15-one in rats and mice.固醇合成抑制剂。膳食中5α-胆甾-8(14)-烯-3β-醇-15-酮对大鼠和小鼠的降胆固醇作用。
Biochem Biophys Res Commun. 1977 Oct 24;78(4):1227-33. doi: 10.1016/0006-291x(77)91424-3.
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Inhibitors of sterol synthesis. Hypocholesterolemic action of dietary 9 alpha-fluoro-5 alpha-cholest-8(14)-en-3 beta-ol-15-one.固醇合成抑制剂。膳食中9α-氟-5α-胆甾-8(14)-烯-3β-醇-15-酮的降胆固醇作用。
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Inhibitors of sterol synthesis. Dietary administration of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats.固醇合成抑制剂。给经淋巴管插管的大鼠经饮食给予5α-胆甾-8(14)-烯-3β-醇-15-酮可抑制胆固醇的肠道吸收。
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1003-8. doi: 10.1016/0006-291x(87)90747-9.
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Inhibitors of sterol synthesis. The effects of dietary 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on the fate of [4-14C]cholesterol and [2,4-3H]5 alpha-cholest-8(14)-en-3 beta-ol-15-one after intragastric administration to rats.固醇合成抑制剂。大鼠经胃内给予膳食5α-胆甾-8(14)-烯-3β-醇-15-酮后，其对[4-¹⁴C]胆固醇和[2,4-³H]5α-胆甾-8(14)-烯-3β-醇-15-酮代谢命运的影响。
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Inhibition of hepatic sterol synthesis and reduction of serum cholesterol in rats by 5alpha-cholest-8(14)-en-3beta-ol-15-one.5α-胆甾-8(14)-烯-3β-醇-15-酮对大鼠肝脏甾醇合成的抑制作用及血清胆固醇的降低
Biochem Biophys Res Commun. 1976 Aug 23;71(4):98409. doi: 10.1016/0006-291x(76)90751-8.
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5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.5α-胆甾-8(14)-烯-3β-醇-15-酮，一种有效的甾醇生物合成抑制剂，可降低狒狒的血清胆固醇并改变脂蛋白中胆固醇的分布。
Proc Natl Acad Sci U S A. 1982 May;79(9):3042-6. doi: 10.1073/pnas.79.9.3042.
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Inhibitors of sterol synthesis. Effect of dietary 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on ACAT activity of jejunal microsomes of the rat.
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Inhibitors of sterol synthesis. Effects of dietary 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on early enzymes in hepatic cholesterol biosynthesis.固醇合成抑制剂。膳食中5α-胆甾-8(14)-烯-3β-醇-15-酮对肝脏胆固醇生物合成早期酶的影响。
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Inhibition of sterol synthesis in animal cells by 15-oxygenated sterols with the unnatural cis-C-D ring junction-"5alpha,14beta-cholest-7-en-15alpha-ol-3-one and 5alpha,14beta-cholest-7-en-15beta-ol-3-one.具有非天然顺式C-D环连接的15-氧化甾醇——“5α,14β-胆甾-7-烯-15α-醇-3-酮和5α,14β-胆甾-7-烯-15β-醇-3-酮对动物细胞中甾醇合成的抑制作用。
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Possible hypocholesterolemic action of 15-ketosterol: replacement of dietary cholesterol absorption.15-酮甾醇可能的降胆固醇作用：替代膳食胆固醇吸收。
Proc Natl Sci Counc Repub China B. 1988 Jul;12(3):115-23.
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5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons.5α-胆甾-8(14)-烯-3β-醇-15-酮，一种有效的甾醇生物合成抑制剂，可降低狒狒的血清胆固醇并改变脂蛋白中胆固醇的分布。
Proc Natl Acad Sci U S A. 1982 May;79(9):3042-6. doi: 10.1073/pnas.79.9.3042.
3
5 alpha-Cholest-8(14)-en-3 beta-ol-15-one lowers serum cholesterol and induces profound changes in the levels of lipoprotein cholesterol and apoproteins in monkeys fed a diet of moderate cholesterol content.5α-胆甾-8(14)-烯-3β-醇-15-酮可降低血清胆固醇，并使喂食中等胆固醇含量饮食的猴子的脂蛋白胆固醇和载脂蛋白水平发生显著变化。
Proc Natl Acad Sci U S A. 1984 Nov;81(21):6861-5. doi: 10.1073/pnas.81.21.6861.
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Oxysterols: chemical synthesis, biosynthesis and biological activities.氧化甾醇：化学合成、生物合成及生物活性
Lipids. 1986 Jan;21(1):27-30. doi: 10.1007/BF02534299.
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Inhibition of cholesterol synthesis by oxygenated sterols.氧化甾醇对胆固醇合成的抑制作用。
Lipids. 1978 Oct;13(10):704-7. doi: 10.1007/BF02533749.
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