Karrh B W, Pell S
Ann N Y Acad Sci. 1982;381:91-6. doi: 10.1111/j.1749-6632.1982.tb50371.x.
A study of brain cancer was conducted in the Du Pont Company to compare the Company's morbidity and mortality experience with that in the U. S. population. Incidence in the Company from 1956 through 1979 was compared to incidence reported in the Third National Cancer Survey, 1969-1971. Mortality from 1957 through 1979 was compared to U. S. mortality in 1968. The morbidity data were confined to active employees, whereas the mortality data included both active and retired employees. Neither data included former employees who left employment without a pension. During these study periods, there were 150 newly diagnosed brain cancer cases and 144 deaths from brain cancer. The data indicated that both morbidity and mortality in the company were essentially the same as in the general population. These results, however, do not preclude the possibility that there could be a group of workers in the company with an excess risk of brain cancer as a result of exposure to a carcinogen, although we are not aware of such a group. The identification of such a group, if it does exist, would have to be made by a case-control or prospective cohort study. Comparisons between male wage roll and salaried employees showed no difference in morbidity and no significant difference in mortality.
杜邦公司开展了一项脑癌研究,以比较该公司的发病率和死亡率情况与美国总体人群的情况。将公司1956年至1979年的发病率与1969 - 1971年第三次全国癌症调查中报告的发病率进行比较。将1957年至1979年的死亡率与1968年美国的死亡率进行比较。发病数据仅限于在职员工,而死亡数据包括在职和退休员工。两组数据均未包括未领取养老金就离职的前员工。在这些研究期间,有150例新诊断的脑癌病例和144例脑癌死亡病例。数据表明,该公司的发病率和死亡率与普通人群基本相同。然而,这些结果并不排除公司中可能存在因接触致癌物而患脑癌风险过高的一组工人的可能性,尽管我们并未发现这样一组人群。如果确实存在这样一组人群,必须通过病例对照研究或前瞻性队列研究来确定。男性在册工资员工和受薪员工之间的比较显示,发病率没有差异,死亡率也没有显著差异。