Hendershott L, Gentilcore R, Ordway F, Fletcher J, Donati R
Eur J Nucl Med. 1982;7(5):234-6. doi: 10.1007/BF00256471.
Lipid soluble agents which chelate radioactive cations have several potential uses in nuclear medicine including: brain imaging, labeling of blood elements, and identifying fatty infiltration of organs. A tropolone-gallium complex has been characterized by the determination of in vitro partition ratios correlated with in vivo organ distribution in the rat. Partition ratios were determined for gallium-67 citrate, indium-114m chloride, and iron-59 chloride cations complexed with tropolone in chloroform + water, octanol + water, olive oil + water, and olive oil + plasma two-phased systems. Tropolone proved to be highly effective in the lipid solubilization of these metal cations. Distribution studies in animals of these cations complexed with tropolone demonstrated an increased concentration of these cation complexes in tissues of high lipid content when compared with appropriate controls.
能螯合放射性阳离子的脂溶性试剂在核医学中有多种潜在用途，包括：脑成像、血液成分标记以及识别器官的脂肪浸润。已通过测定体外分配比（与大鼠体内器官分布相关）对一种托酚酮 - 镓络合物进行了表征。在氯仿 + 水、辛醇 + 水、橄榄油 + 水以及橄榄油 + 血浆双相体系中，测定了与托酚酮络合的柠檬酸镓 -67、氯化铟 -114m 和氯化铁 -59 阳离子的分配比。结果表明托酚酮在这些金属阳离子的脂溶性溶解方面非常有效。与适当对照相比，对这些与托酚酮络合的阳离子在动物体内的分布研究表明，在高脂含量组织中这些阳离子络合物的浓度有所增加。
