Dewanjee M K, Rao S A, Rosemark J A, Chowdhury S, Didisheim P
Radiology. 1982 Oct;145(1):149-53. doi: 10.1148/radiology.145.1.6812158.
Platelets have been labeled with a new neutral, lipid-soluble metal complex of indium 111 (111In) and tropolone. Unlike oxine, which is soluble in ethyl alcohol, tropolone is soluble in isotonic saline. Platelet labeling with 111In tropolone can be performed in both acid-citrate-dextrose (ACD) plasma and ACD saline within two hours. Labeling efficiency has been 80% to 90%. 111In tropolone in ACD saline and ACD plasma at tropolone concentrations of 5 and 10 micrograms/ml, respectively, and incubation of the platelets with the tracer at room temperature for 20 minutes were optimal conditions for labeling. The authors have developed an ACD-saline kit for convenient preparation of 111In-labeled platelets. No adverse effect of 111In tropolone on platelets has been observed in studies of biodistribution, recovery, and survival of platelets in rabbits and dogs.
血小板已用一种新的铟111（¹¹¹In）与托酚酮形成的中性脂溶性金属络合物进行了标记。与可溶于乙醇的8-羟基喹啉不同，托酚酮可溶于等渗盐溶液。用¹¹¹In托酚酮标记血小板可在两小时内在酸性枸橼酸盐葡萄糖（ACD）血浆和ACD盐溶液中进行。标记效率为80%至90%。分别在托酚酮浓度为5微克/毫升和10微克/毫升的ACD盐溶液和ACD血浆中，以及在室温下将血小板与示踪剂孵育20分钟，是标记的最佳条件。作者开发了一种ACD盐溶液试剂盒，便于制备¹¹¹In标记的血小板。在对兔和犬血小板的生物分布、回收率和存活率的研究中，未观察到¹¹¹In托酚酮对血小板有不良影响。
