食物限制在延缓衰老过程中的作用。
Action of food restriction in delaying the aging process.
作者信息
Masoro E J, Yu B P, Bertrand H A
出版信息
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4239-41. doi: 10.1073/pnas.79.13.4239.
Abstract
Food restriction has long been known to prolong life in rodents, and recent studies have shown it to have antiaging effects in regard to a variety of physiologic and pathologic processes. It has been suggested that these actions of food restriction relate to the reduction of metabolic rate per unit of body mass brought about by this dietary regimen. Data are presented in this report showing that food restriction can have a marked life-prolonging action in rats without reducing caloric intake per gram of body weight. Moreover, the food-restricted rats consumed a greater number of calories per gram of body weight during their lifetimes than did the rats fed ad lib, yet they lived longer. Thus, the data in this report do not support the concept that food restriction slows the rate of aging by decreasing the metabolic rate.
摘要
长期以来，人们都知道食物限制能延长啮齿动物的寿命，最近的研究表明，在各种生理和病理过程方面，食物限制具有抗衰老作用。有人提出，食物限制的这些作用与这种饮食方案导致的单位体重代谢率降低有关。本报告提供的数据表明，食物限制在不降低每克体重热量摄入的情况下，对大鼠具有显著的延长寿命作用。此外，食物受限的大鼠在其一生中每克体重消耗的卡路里数量比自由进食的大鼠更多，但它们活得更长。因此，本报告中的数据并不支持食物限制通过降低代谢率来减缓衰老速度这一观点。
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