Müller-Lissner S A, Fraass C
Dig Dis Sci. 1985 Aug;30(8):733-8. doi: 10.1007/BF01320486.
Duodenogastric reflux of a perfused marker and bile salt reflux, as well as emptying of fasting gastric contents and gastric secretion, were measured simultaneously in six healthy volunteers. Each of the subjects was studied three times in randomized order during intravenous administration of either saline or atropine (40 micrograms/kg/4 hr) or cerulein (360 ng/kg/4 hr). Fractional gastric emptying rate was inhibited from 4.57%/min +/- 0.50 SE to 0.70 +/- 0.15 by atropine (P less than 0.001) and to 1.80 +/- 0.29 by cerulein (P less than 0.005). Atropine increased reflux of duodenally perfused phenol red from 0.95 +/- 0.28 to 26.09 +/- 4.98% (P less than 0.005) without affecting bile salt reflux (0.44 +/- 0.07 vs 0.51 +/- 0.17 mumol/min). In contrast, cerulein did not significantly affect duodenogastric marker reflux (2.23 +/- 0.82%) but increased bile salt reflux to 0.94 +/- 0.16 mumol/min (P less than 0.05). It is concluded that reflux of duodenal contents and reflux of bile salts do not necessarily parallel each other. This may produce considerable confusion by apparently contradictory results in studies on duodenogastric reflux.
在6名健康志愿者中同时测量了灌注标记物的十二指肠-胃反流、胆盐反流以及空腹胃内容物排空和胃分泌情况。在静脉注射生理盐水、阿托品（40微克/千克/4小时）或雨蛙肽（360纳克/千克/4小时）期间，每位受试者按随机顺序接受了3次研究。阿托品使胃排空分数率从4.57%/分钟±0.50标准误降至0.70±0.15（P<0.001），雨蛙肽使其降至1.80±0.29（P<0.005）。阿托品使十二指肠灌注酚红的反流从0.95±0.28增加至26.09±4.98%（P<0.005），而不影响胆盐反流（0.44±0.07对0.51±0.17微摩尔/分钟）。相比之下，雨蛙肽对十二指肠-胃标记物反流无显著影响（2.23±0.82%），但使胆盐反流增加至平均0.94±0.16微摩尔/分钟（P<0.05）。结论是十二指肠内容物反流和胆盐反流不一定相互平行。这可能会在十二指肠-胃反流研究中因明显矛盾的结果而产生相当大的混淆。
