Lai K N, Aarons I, Woodroffe A J, Clarkson A R
Aust N Z J Med. 1982 Aug;12(4):276-9. doi: 10.1111/j.1445-5994.1982.tb03811.x.
Renal function studies and kidney biopsies were performed in four patients presenting with renal insufficiency and acute Leptospira pomona infection. The renal lesion in all patients revealed acute interstitial nephritis. There was no evidence of immunologically mediated disease in three patients who were biopsied seven, eight and eight days respectively following the onset of symptoms. The fourth, in whom there was no evidence of prior renal disease, and whose biopsy was performed 16 days after symptoms began, showed glomerular Clq, and C3 immunofluorescence and mesangial, subepithelial and intramembranous dense deposits by electron microscopy. In addition, circulating immune complexes were demonstrated in this patient. These findings suggest that in this instance at least, the renal lesions of Leptospira pomona infections can be immunologically mediated. Because this may well be a transient phase, the timing of investigations could be crucial to its detection.
对4例出现肾功能不全并感染波摩那钩端螺旋体的患者进行了肾功能研究和肾活检。所有患者的肾损害均显示为急性间质性肾炎。分别在症状出现后7天、8天和8天接受活检的3例患者中，没有免疫介导疾病的证据。第4例患者在症状出现前没有肾脏疾病的证据，在症状开始16天后进行活检，显示肾小球Clq和C3免疫荧光，电子显微镜检查显示系膜、上皮下和膜内致密沉积物。此外，该患者体内检测到循环免疫复合物。这些发现表明，至少在这种情况下，波摩那钩端螺旋体感染的肾损害可能是由免疫介导的。由于这很可能是一个短暂阶段，检查的时机对于其检测可能至关重要。
