Helin H, Pasternack A, Hakala T, Penttinen K, Wager O
Clin Nephrol. 1980 Jul;14(1):23-30.
39 patients with malignant neoplasms were studied for the presence of paraneoplastic glomerular disease. The nephrotic syndrome was found in none of the patients. From 24 patients an adequate renal biopsy specimen was available for examination by electron microscopy. Glomerular electron-dense deposits were found in the biopsies of 11 patients, and in four of them the deposits were subepithelial. Circulating soluble immune complexes were detected in the sera of 14 patients. Deposits and circulating immune complexes occurred simultaneously with a highly significant correlation. Cell-mediated immunity was studied using skin tests to tuberculin and dinitrochlorobenzene (DNCB). Negative tests were seen mainly in patients with circulating immune complexes and/or glomerular deposits. Median survival time in patients with deposits or circulating complexes tended to be shorter than in those without.
对39例恶性肿瘤患者进行了副肿瘤性肾小球疾病的研究。所有患者均未发现肾病综合征。24例患者有足够的肾活检标本可供电子显微镜检查。11例患者的活检中发现肾小球电子致密沉积物，其中4例为上皮下沉积物。14例患者血清中检测到循环可溶性免疫复合物。沉积物和循环免疫复合物同时出现，具有高度显著的相关性。采用结核菌素和二硝基氯苯（DNCB）皮肤试验研究细胞介导的免疫。阴性试验主要见于有循环免疫复合物和/或肾小球沉积物的患者。有沉积物或循环复合物的患者的中位生存时间往往比没有的患者短。
