花生四烯酸脂氧合酶的氢过氧酸和羟酸产物对兔皮肤的炎症作用。
The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin.
作者信息
Higgs G A, Salmon J A, Spayne J A
出版信息
Br J Pharmacol. 1981 Oct;74(2):429-33. doi: 10.1111/j.1476-5381.1981.tb09988.x.
Abstract
- The inflammatory effects of hydroperoxy (HPETE) and hydroxy (HETE) acids, synthesized by arachidonic acid lipoxygenases, have been investigated in rabbit skin. 2. High doses (10-20 micrograms) of 5-, 12- or 15-HPETE or the 5,12-di-hydroxy acid, leukotriene B4 (0.1-1 micrograms), caused small but significant increases in plasma exudation following intra-dermal injection. 3. Leukotriene B4 was equipotent with prostaglandin E2 and prostacyclin in potentiating bradykinin-induced plasma exudation, and was 100 times more active in this property than any other lipoxygenase product tested. 4. Leukotriene B4-induced plasma exudation was enhanced by prostaglandin E2. 5. The mono-HETEs were relatively inactive in causing or enhancing plasma exudation. 6. Leukotriene B4 (0.1 microgram) or prostaglandin E1 (1.0 micrograms) significantly elevated leukocyte accumulation in rabbit skin, whereas PGE2, 5-HPETE, 5-HETE, 12-HPETE or 12-HETE were inactive at doses up to 1 microgram.
摘要
- 花生四烯酸脂氧合酶合成的氢过氧（HPETE）和羟基（HETE）酸的炎症效应已在兔皮肤中进行了研究。2. 高剂量（10 - 20微克）的5-、12-或15-HPETE或5,12-二羟基酸白三烯B4（0.1 - 1微克），皮内注射后导致血浆渗出有小但显著的增加。3. 白三烯B4在增强缓激肽诱导的血浆渗出方面与前列腺素E2和前列环素等效，并且在这一特性上比所测试的任何其他脂氧合酶产物活性高100倍。4. 前列腺素E2增强了白三烯B4诱导的血浆渗出。5. 单-HETEs在引起或增强血浆渗出方面相对无活性。6. 白三烯B4（0.1微克）或前列腺素E1（1.0微克）显著提高兔皮肤中的白细胞聚集，而前列腺素E2、5-HPETE、5-HETE、12-HPETE或12-HETE在高达1微克的剂量下无活性。
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