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花生四烯酸脂氧合酶的氢过氧酸和羟酸产物对兔皮肤的炎症作用。

The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin.

作者信息

Higgs G A, Salmon J A, Spayne J A

出版信息

Br J Pharmacol. 1981 Oct;74(2):429-33. doi: 10.1111/j.1476-5381.1981.tb09988.x.

DOI:10.1111/j.1476-5381.1981.tb09988.x
PMID:6274465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071731/
Abstract
  1. The inflammatory effects of hydroperoxy (HPETE) and hydroxy (HETE) acids, synthesized by arachidonic acid lipoxygenases, have been investigated in rabbit skin. 2. High doses (10-20 micrograms) of 5-, 12- or 15-HPETE or the 5,12-di-hydroxy acid, leukotriene B4 (0.1-1 micrograms), caused small but significant increases in plasma exudation following intra-dermal injection. 3. Leukotriene B4 was equipotent with prostaglandin E2 and prostacyclin in potentiating bradykinin-induced plasma exudation, and was 100 times more active in this property than any other lipoxygenase product tested. 4. Leukotriene B4-induced plasma exudation was enhanced by prostaglandin E2. 5. The mono-HETEs were relatively inactive in causing or enhancing plasma exudation. 6. Leukotriene B4 (0.1 microgram) or prostaglandin E1 (1.0 micrograms) significantly elevated leukocyte accumulation in rabbit skin, whereas PGE2, 5-HPETE, 5-HETE, 12-HPETE or 12-HETE were inactive at doses up to 1 microgram.
摘要
  1. 花生四烯酸脂氧合酶合成的氢过氧（HPETE）和羟基（HETE）酸的炎症效应已在兔皮肤中进行了研究。2. 高剂量（10 - 20微克）的5-、12-或15-HPETE或5,12-二羟基酸白三烯B4（0.1 - 1微克），皮内注射后导致血浆渗出有小但显著的增加。3. 白三烯B4在增强缓激肽诱导的血浆渗出方面与前列腺素E2和前列环素等效，并且在这一特性上比所测试的任何其他脂氧合酶产物活性高100倍。4. 前列腺素E2增强了白三烯B4诱导的血浆渗出。5. 单-HETEs在引起或增强血浆渗出方面相对无活性。6. 白三烯B4（0.1微克）或前列腺素E1（1.0微克）显著提高兔皮肤中的白细胞聚集，而前列腺素E2、5-HPETE、5-HETE、12-HPETE或12-HETE在高达1微克的剂量下无活性。

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本文引用的文献

1
Control of vascular permeability by polymorphonuclear leukocytes in inflammation.炎症中多形核白细胞对血管通透性的控制
Nature. 1981 Feb 19;289(5799):646-50. doi: 10.1038/289646a0.
2
The action of chemically pure SRS-A on the microcirculation in vivo.化学纯的慢反应物质A（SRS-A）对体内微循环的作用。
Prostaglandins. 1980 May;19(5):779-89. doi: 10.1016/0090-6980(80)90174-4.
3
Nomenclature for leukotrienes.白三烯的命名法。
Prostaglandins. 1980 May;19(5):645-8. doi: 10.1016/0090-6980(80)90099-4.
4
The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation.非甾体抗炎药对角叉菜胶诱导的炎症中白细胞迁移的影响。
Eur J Pharmacol. 1980 Aug 22;66(1):81-6. doi: 10.1016/0014-2999(80)90297-6.
5
Leukotrienes and slow reacting substance of anaphylaxis (SRS-A).白三烯与过敏反应迟缓反应物质（SRS-A）。
Allergy. 1980 Jul;35(5):375-81. doi: 10.1111/j.1398-9995.1980.tb01782.x.
6
Leukotriene B4: a mediator of vascular permeability.白三烯B4：血管通透性的介质
Br J Pharmacol. 1981 Mar;72(3):483-6. doi: 10.1111/j.1476-5381.1981.tb11000.x.
7
Chemokinetic activity of arachidonic and lipoxygenase products on leuocyctes of different species.花生四烯酸和脂氧合酶产物对不同物种白细胞的趋化活性。
Prostaglandins. 1980 Aug;20(2):411-8. doi: 10.1016/s0090-6980(80)80058-x.
8
Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes.白三烯B，一种从多形核白细胞释放的强效化学趋化和聚集物质。
Nature. 1980 Jul 17;286(5770):264-5. doi: 10.1038/286264a0.
9
Leukotriene B: a potential mediator of inflammation.白三烯B：一种潜在的炎症介质。
J Pharm Pharmacol. 1980 Jul;32(7):517-8. doi: 10.1111/j.2042-7158.1980.tb12985.x.
10
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets.前列腺素内过氧化物。人血小板中花生四烯酸的新转化。
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3400-4. doi: 10.1073/pnas.71.9.3400.