日本t(8q - ;21q+)和t(15q + ;17q-)易位白血病的细胞遗传学、形态学及临床数据总结

A summary of cytogenetic, morphologic, and clinical data on t(8q - ;21q+) and t(15q + ;17q-) translocation leukemias in Japan.

作者信息

Sakurai M, Sasaki M, Kamada N, Okada M, Oshimura M, Ishihara T, Shiraishi Y

出版信息

Cancer Genet Cytogenet. 1982 Sep;7(1):59-65. doi: 10.1016/0165-4608(82)90108-x.

Abstract

Cytogenetic, morphologic, and clinical data of 33 acute nonlymphocytic leukemia (ANLL) patients with t(8q - ;21q+) and 19 patients with acute promyelocytic leukemia (APL) were collected from seven laboratories in Japan. The latter class included 18 patients with t(15q + ;17q-) and one with a normal karyotype. The t(8q - ;21q+) and t(15q + ;17q-) translocations were each shown to be associated with a specific type of ANLL, namely, AML-M2 and APL-M3, respectively. No patient with APL had the M3 variant. The t(8q - ;21q+) translocation seems to be more common as an abnormality in ANLL in Japan as compared to findings in other countries. The high incidence of t(15q + ;17q-) among Japanese patients with APL indicated in this study, however, still awaits confirmation.

摘要

从日本的七个实验室收集了33例伴有t(8q - ;21q+)的急性非淋巴细胞白血病（ANLL）患者以及19例急性早幼粒细胞白血病（APL）患者的细胞遗传学、形态学和临床数据。后一组包括18例伴有t(15q + ;17q-)的患者和1例核型正常的患者。t(8q - ;21q+)和t(15q + ;17q-)易位分别与特定类型的ANLL相关，即分别与AML-M2和APL-M3相关。没有APL患者具有M3变异型。与其他国家的研究结果相比，t(8q - ;21q+)易位在日本ANLL中似乎作为一种异常更为常见。然而，本研究中日本APL患者中t(15q + ;17q-)的高发生率仍有待证实。