急性早幼粒细胞白血病中的染色体异常
Chromosomal abnormalities in acute promyelocytic leukaemia.
作者信息
de la Chapelle A, Knuutila S, Elonen E, Vuopio P
出版信息
Scand J Haematol. 1981 Jan;26(1):57-60. doi: 10.1111/j.1600-0609.1981.tb01624.x.
In 2 patients with acute promyelocytic leukaemia (APL) an isochromosome for the long arm of chromosome 17 was seen in part of the bone marrow mitoses at diagnosis and relapse, respectively. In one of them, there was a t(15q+; 17q-) affecting one of the No. 15 chromosomes and both arms of the isochromosome. Thus the translocations must have occurred before (or simultaneously with) the formation of the isochromosome. This is the first example of t(15;17) out of 17 patients with APL studied in Finland.
在2例急性早幼粒细胞白血病（APL）患者中，分别在诊断和复发时的部分骨髓有丝分裂中观察到17号染色体长臂的等臂染色体。其中1例存在t(15q+; 17q-)，涉及一条15号染色体和等臂染色体的两条臂。因此，易位肯定发生在等臂染色体形成之前（或与之同时）。这是芬兰研究的17例APL患者中首例t(15;17)。
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