急性早幼粒细胞白血病的进一步细胞遗传学研究
Further cytogenetic studies on acute promyelocytic leukemia.
作者信息
Kondo K, Sasaki M
出版信息
Cancer Genet Cytogenet. 1982 May;6(1):39-46. doi: 10.1016/0165-4608(82)90019-x.
Chromosomes were analyzed in nine cases of acute promyelocytic leukemia (APL-M3), including a follow-up case and an erroneously diagnosed case from our previous reports. The reciprocal 15;17 translocation, t(15q+; 17q-), was found in all cases, and the break points were estimated to be 15q22 or q23 and 17q12. In addition, trisomy 8 and an isochromosome of the long arm of the affected chromosome #17, i(17q-), were observed in two cases each. Some other abnormalities were encountered, mostly in remission or relapse. The disappearance and repopulation of t(15q+; 17q-) cells were associated with complete remission and relapse, respectively, in two repeatedly analyzed cases. Including the previously reported cases, we investigated a total of 12 cases of APL, and all were found to be associated with t(15q; 17q-). The mean age of the 12 patients was 34.25 +/- 3.12 [SD] years, and their mean survival 266.3 +/- 95.97 [SD] days.
对9例急性早幼粒细胞白血病（APL-M3）进行了染色体分析，包括1例随访病例和1例我们之前报告中误诊的病例。所有病例均发现了相互易位15;17，即t(15q+; 17q-)，断点估计在15q22或q23以及17q12。此外，各有2例观察到8号染色体三体和受累的17号染色体长臂等臂染色体，即i(17q-)。还发现了一些其他异常，大多出现在缓解期或复发期。在2例重复分析的病例中，t(15q+; 17q-)细胞的消失和再现分别与完全缓解和复发相关。包括之前报告的病例，我们共研究了12例APL，均发现与t(15q; 17q-)相关。12例患者的平均年龄为34.25 +/- 3.12 [标准差]岁，平均生存期为266.3 +/- 95.97 [标准差]天。
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