Witte J L, Sapico F L, Canawati H N
Antimicrob Agents Chemother. 1982 Nov;22(5):906-8. doi: 10.1128/AAC.22.5.906.
A total of 82 clinical isolates of methicillin-resistant Staphylococcus aureus and 21 isolates of methicillin-susceptible S. aureus were studied for in vitro susceptibility to N-forminidoyl thienamycin at incubation temperatures of 30 and 35 degrees C. The disk diffusion test results were correlated with the macrobroth dilution test by means of the error rate-bounded method of analysis. Both methicillin-susceptible and (to a lesser degree) methicillin-resistant strains were generally susceptible to the antibiotic as judged from their minimum inhibitory concentrations. The discrepancy between in vitro results obtained at 30 and at 35 degrees C was not very remarkable. However, tolerance of N-formimidoyl thienamycin was observed in 37% of methicillin-resistant strains and 24% of methicillin-susceptible strains at an incubation temperature of 30 degrees C; at 35 degrees C, the values were 54% (methicillin-resistant strains) and 14% (methicillin-susceptible strains).
对82株耐甲氧西林金黄色葡萄球菌临床分离株和21株甲氧西林敏感金黄色葡萄球菌分离株在30℃和35℃培养温度下进行了对N-甲酰亚胺硫霉素的体外敏感性研究。采用误差率受限分析法将纸片扩散试验结果与常量肉汤稀释试验结果进行关联分析。从最低抑菌浓度判断，甲氧西林敏感菌株和（程度较轻的）耐甲氧西林菌株通常对该抗生素敏感。在30℃和35℃获得的体外结果差异不太显著。然而，在30℃培养温度下，37%的耐甲氧西林菌株和24%的甲氧西林敏感菌株观察到对N-甲酰亚胺硫霉素的耐受性；在35℃时，相应数值分别为54%（耐甲氧西林菌株）和14%（甲氧西林敏感菌株）。
