金黄色葡萄球菌菌株对苯唑西林、头孢噻吩和庆大霉素敏感性的差异。
Variation in the susceptibility of strains of Staphylococcus aureus to oxacillin, cephalothin, and gentamicin.
作者信息
Mayhall C G, Medoff G, Marr J J
出版信息
Antimicrob Agents Chemother. 1976 Oct;10(4):707-12. doi: 10.1128/AAC.10.4.707.
Abstract
Three cases of staphylococcal bacteremia caused by organisms that were inhibited by low concentrations of oxacillin, but were resistant to the killing effects of oxacillin, stimulated us to screen 60 clinical isolates of Staphylococcus aureus for their susceptibility to oxacillin, cephalothin, and gentamicin. All 60 strains were inhibited by low concentrations of the antibiotics. The antibiotics were bactericidal against 27 of the 60 strains and only bacteriostatic against the other 33 after 24 h of incubation. However, after 48 h of incubation, the antibiotics were also bactericidal against the latter group.
摘要
三例葡萄球菌菌血症由对低浓度苯唑西林敏感但对其杀菌作用耐药的菌株引起，这促使我们对60株金黄色葡萄球菌临床分离株进行苯唑西林、头孢噻吩和庆大霉素敏感性检测。所有60株菌株均被低浓度抗生素抑制。孵育24小时后，这些抗生素对60株菌株中的27株具有杀菌作用，而对另外33株仅具有抑菌作用。然而，孵育48小时后，这些抗生素对后一组菌株也具有杀菌作用。
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本文引用的文献
1
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Acta Pathol Microbiol Scand. 1964;62:255-75. doi: 10.1111/apm.1964.62.2.255.
2
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J Gen Microbiol. 1964 May;35:335-49. doi: 10.1099/00221287-35-2-335.
3
NATURALLY OCCURING METHICILLIN-RESISTANT STAPHYLOCOCCI.天然存在的耐甲氧西林葡萄球菌
J Gen Microbiol. 1964 May;35:183-90. doi: 10.1099/00221287-35-2-183.
4
CHARACTERISTICS OF METHICILLIN-RESISTANT STAPHYLOCOCCI.耐甲氧西林葡萄球菌的特征
J Bacteriol. 1964 Apr;87(4):887-99. doi: 10.1128/jb.87.4.887-899.1964.
5
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Am J Clin Pathol. 1966 Apr;45(4):493-6.
6
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Am J Med. 1973 Apr;54(4):473-81. doi: 10.1016/0002-9343(73)90043-0.
7
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8
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