Shimomura O, Suthers H L, Bonner J T
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7376-9. doi: 10.1073/pnas.79.23.7376.
The aggregation chemoattractant (or acrasin) of Polysphondylium violaceum, a species of cellular slime mold that does not respond chemotactically to cAMP, has been identified. It was extracted and purified from aggregating amoebae, then analyzed for amino acid composition and by IR and mass spectrometry. The active molecule is N-propionyl-gamma-L-glutamyl-L-ornithine-delta-lactam ethyl ester (Mr, 327), which we have named glorin. The compound has been synthesized and shows normal chemotactic activity with the amoebae of P. violaceum.
已鉴定出紫聚孢黏菌（一种对环磷酸腺苷无趋化反应的细胞黏菌）的聚集化学引诱剂（或聚集素）。它是从聚集变形虫中提取并纯化的，然后对其氨基酸组成进行分析，并通过红外光谱和质谱分析。活性分子是N-丙酰基-γ-L-谷氨酰-L-鸟氨酸-δ-内酰胺乙酯（分子量327），我们将其命名为聚孢黏菌素。该化合物已合成，并对紫聚孢黏菌的变形虫显示出正常的趋化活性。
