免疫系统与胎儿源性癌症。
The immune system and cancers of foetal origin.
作者信息
Stewart A M, Kneale G W
机构信息
Department of Social Medicine, University of Birmingham, Great Britain.
出版信息
Cancer Immunol Immunother. 1982;14(2):110-6. doi: 10.1007/BF00200178.
Evidence of early loss of immunological competence in cases of neoplasms occurring in juveniles was found in an analysis of OSCC data (Oxford Survey of Childhood Cancers). The effects observed included heightened sensitivity to infection from birth onwards for all types of childhood cancer, higher levels of sensitivity for leukaemia than for lymphomas, and higher levels for lymphomas than for other solid tumours. The findings as a whole are consistent with in utero loss of immunological competence, which is an essential promoter of cancers of foetal origin and thus allows the outcome of an in utero cancer induction to be influenced both by maternal levels of immunological competence and postnatal infection.
在一项对口腔鳞状细胞癌数据（牛津儿童癌症调查）的分析中，发现了青少年肿瘤病例中早期免疫能力丧失的证据。观察到的影响包括，所有类型的儿童癌症从出生起对感染的敏感性增加，白血病的敏感性水平高于淋巴瘤，淋巴瘤的敏感性水平高于其他实体瘤。总体研究结果与子宫内免疫能力丧失相符，子宫内免疫能力丧失是胎儿源性癌症的重要促进因素，因此子宫内癌症诱导的结果会受到母亲免疫能力水平和产后感染的影响。
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