Peyrol S, Grimaud J A, Pirson Y, Chayvialle J A, Touillon C, Lambert B
J Histochem Cytochem. 1977 Jun;25(6):432-8. doi: 10.1177/25.6.69654.
Cells producing alpha-fetoprotein in human fetal liver have been studied with specific horseradish peroxidase labeled immunoglobulins. Under light microscopy, the alpha-fetoprotein is strictly localized in the cytoplasm of certain hepatocytes, distributed randomly in the hepatic lobule. Ultrastructural examination of thesame cells shows that the alpha-fetoprotein is present within the cytoplasm. Ultrastructural differences are described in hepatocytes according to whether or not the cell is producing alpha-fetoprotein at the time of sampling. These observations lead to the hypothesis that alpha-fetoprotein may correspond to a particular functional state of the hepatocyte in human fetal liver.
利用特异性辣根过氧化物酶标记的免疫球蛋白，对人胎儿肝脏中产生甲胎蛋白的细胞进行了研究。在光学显微镜下，甲胎蛋白严格定位于某些肝细胞的细胞质中，随机分布于肝小叶内。对这些细胞的超微结构检查显示，甲胎蛋白存在于细胞质中。根据取样时细胞是否产生甲胎蛋白，描述了肝细胞的超微结构差异。这些观察结果提出了一个假设，即甲胎蛋白可能与人胎儿肝脏中肝细胞的一种特定功能状态相对应。
