Peyrol S, Grimaud J A, Chayvialle J A, Veyre B, Paliard P, Lambert R
Digestion. 1978;18(5-6):351-70. doi: 10.1159/000198222.
5 human cases of hepatoma have been chosen with respect to their different seric alpha-fetoprotein (alpha-FP) level and histological characters. Cells producing alpha-FP have been studied with specific horseradish-peroxidase-labelled immunoglobulins. Ultrastructural examination shows that alpha-FP is present in the cytoplasm of some tumoral hepatocytes. alpha-FP is also present in the cytoplasm of some rare nontumoral hepatocytes of a nonsecreting hepatoma. Ultrastructural differences are described in tumoral hepatocytes according to the grade of differentiation of the tumoral cell population. alpha-FP production appears to be restricted to moderately differentiated tumoral hepatocytes. These observations led to the hypothesis that production of alpha-FP may transiently develop either during the differentiation of tumoral hepatocytes, or during the new differentiation of nontumoral hepatocytes involved in a proliferative process.
选取了5例肝癌患者，根据其不同的血清甲胎蛋白（α-FP）水平和组织学特征进行研究。利用特异性辣根过氧化物酶标记的免疫球蛋白对产生α-FP的细胞进行了研究。超微结构检查显示，α-FP存在于部分肿瘤性肝细胞的细胞质中。在一例非分泌型肝癌的一些罕见非肿瘤性肝细胞的细胞质中也发现了α-FP。根据肿瘤细胞群体的分化程度，对肿瘤性肝细胞的超微结构差异进行了描述。α-FP的产生似乎仅限于中度分化的肿瘤性肝细胞。这些观察结果提出了一个假设，即α-FP的产生可能在肿瘤性肝细胞的分化过程中，或者在参与增殖过程的非肿瘤性肝细胞的重新分化过程中短暂出现。
