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疱疹性角膜基质病中的细胞介导免疫

Cell-mediated immunity in herpes corneal stromal disease.

作者信息

Nagy R M, McFall R C, Sery T W

出版信息

Invest Ophthalmol Vis Sci. 1980 Mar;19(3):271-7.

PMID:6965667
Abstract

Regional draining lymph nodes (RDLN) from rabbits with herpes virus disciform keratitis (defined as corneal edema or corneal edema with concomitant epithelial lesions) were tested for general as well as specific immune cap-city. Although general RDLN immune capacity did not seem to be impaired, specific reactivity to herpes antigens was found only in those rabbits which presented with disciform keratitis and concomitant epithelial lesions; specific reactivity to herpes antigens was not found in those animals which presented with disciform edema alone. Additionally, the unilateral nature of the RDLN immune response during ocular infections of unequal severity was demonstrated.

摘要

对患有疱疹病毒性盘状角膜炎(定义为角膜水肿或伴有上皮病变的角膜水肿)的兔子的局部引流淋巴结(RDLN)进行了一般免疫能力和特异性免疫能力检测。虽然RDLN的一般免疫能力似乎未受损,但仅在那些出现盘状角膜炎并伴有上皮病变的兔子中发现了对疱疹抗原的特异性反应;在仅出现盘状水肿的动物中未发现对疱疹抗原的特异性反应。此外,还证明了在严重程度不等的眼部感染期间RDLN免疫反应的单侧性。

相似文献

1
Cell-mediated immunity in herpes corneal stromal disease.疱疹性角膜基质病中的细胞介导免疫
Invest Ophthalmol Vis Sci. 1980 Mar;19(3):271-7.
2
Induction of cell-mediated immunity in herpes simplex virus keratitis. Kinetics of lymphocyte transformation and the effect of antiviral antibody.单纯疱疹病毒性角膜炎中细胞介导免疫的诱导。淋巴细胞转化动力学及抗病毒抗体的作用。
Invest Ophthalmol Vis Sci. 1980 Aug;19(8):920-9.
3
Cell-mediated immune tolerance to HSV-1 antigens associated with reduced susceptibility to HSV-1 corneal lesions.对与单纯疱疹病毒1型(HSV-1)角膜病变易感性降低相关的HSV-1抗原的细胞介导免疫耐受。
Invest Ophthalmol Vis Sci. 1987 Dec;28(12):1986-93.
4
Cell-mediated immune response to herpes simplex virus: type-specific lymphoproliferative responses in lymph nodes draining the site of primary infection.针对单纯疱疹病毒的细胞介导免疫反应:在原发性感染部位引流淋巴结中的型特异性淋巴细胞增殖反应。
J Immunol. 1976 Jun;116(6):1520-5.
5
Immune destruction of rabbit corneal cells infected with herpes simplex virus: lymphocyte reactivity by antibody-dependent cellular cytotoxicity.
Invest Ophthalmol Vis Sci. 1982 Aug;23(2):227-33.
6
Mechanisms of resistance and hypersensitivity in herpes simplex keratitis.单纯疱疹病毒性角膜炎的耐药机制与超敏反应
Trans Ophthalmol Soc U K (1962). 1979 Apr;99(1):126-33.
7
Effects of cyclosporine A on clinical and immunological parameters in herpes simplex keratitis.环孢素A对单纯疱疹病毒性角膜炎临床及免疫学参数的影响。
Invest Ophthalmol Vis Sci. 1987 Jul;28(7):1170-80.
8
Experimental disciform edema and necrotizing keratitis in the rabbit.兔实验性盘状水肿和坏死性角膜炎
Invest Ophthalmol. 1976 Dec;15(12):979-85.
9
Herpes simplex virus-specific T cells infiltrate the cornea of patients with herpetic stromal keratitis: no evidence for autoreactive T cells.单纯疱疹病毒特异性T细胞浸润疱疹性基质性角膜炎患者的角膜:无自身反应性T细胞的证据。
Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2607-12.
10
Activation of glomerular basement membrane-specific B cells in the renal draining lymph node after T cell-mediated glomerular injury.T细胞介导的肾小球损伤后,肾引流淋巴结中肾小球基底膜特异性B细胞的激活。
J Am Soc Nephrol. 2005 Nov;16(11):3256-63. doi: 10.1681/ASN.2005040421. Epub 2005 Sep 14.

引用本文的文献

1
Systemic immunity in herpetic keratitis.疱疹性角膜炎中的全身免疫
Br J Ophthalmol. 1981 Feb;65(2):82-8. doi: 10.1136/bjo.65.2.82.