Easty D L, Carter C, Funk A
Br J Ophthalmol. 1981 Feb;65(2):82-8. doi: 10.1136/bjo.65.2.82.
The importance of specific immunity, especially cell-mediated, in resistance to herpes simplex disease is well documented, and animal experiments show that immune responses to previous herpetic infection can give considerable protection against reinfection in epithelial keratitis. Since susceptibility to stromal herpetic keratitis is probably determined in part by the extent of virus proliferation in the epithelium, immune responses to herpes simplex virus were studied in patients with epithelial or stromal keratitis, a group of patients with keratitis who were also severely atopic, and controls. The parameters measured were lymphocyte transformation, production of macrophage migration inhibition factor, and levels of serum antibody and immunoglobulin. No group differences were found except for a slight decrease in the whole blood culture assessment of lymphocyte transformation in stromal keratitis patients compared with seropositive controls and patients with epithelial disease. It is considered that in a small group of patients a deficiency in the specific cell-mediated immune response plays a role in determining the spread of virus into the corneal stroma.
特异性免疫，尤其是细胞介导免疫在抵抗单纯疱疹疾病中的重要性已有充分记录，动物实验表明，对先前疱疹感染的免疫反应可对上皮性角膜炎的再感染提供相当程度的保护。由于对基质性疱疹性角膜炎的易感性可能部分取决于病毒在上皮中的增殖程度，因此研究了上皮性或基质性角膜炎患者、一组同样患有严重特应性皮炎的角膜炎患者以及对照组对单纯疱疹病毒的免疫反应。所测量的参数包括淋巴细胞转化、巨噬细胞移动抑制因子的产生以及血清抗体和免疫球蛋白水平。除了与血清阳性对照组和上皮性疾病患者相比，基质性角膜炎患者全血培养评估的淋巴细胞转化略有下降外，未发现组间差异。据认为，在一小部分患者中，特异性细胞介导免疫反应的缺陷在决定病毒向角膜基质扩散中起作用。
