Wells R A, Scott R M, Pavanand K, Sathitsathein V, Cheamudon U, Macdermott R P
Infect Immun. 1980 May;28(2):428-33. doi: 10.1128/iai.28.2.428-433.1980.
Peripheral leukocytes from 16 Thai children with dengue hemorrhagic fever were examined to determine the leukocyte composition on the day of presentation and on convalescent days 15 and 30. Mononuclear cells were isolated each time, and the concentrations of T, B, Fc receptor-bearing, and "null" cells were determined. On the day of hospitalization, in comparison to convalescent values, there was a significant increase in total lymphocytes, primarily due to concentrations of atypical lymphocytes. There was a significant loss of T cells with an increase in non-T, non-B, non-Fc receptor-bearing null cells. There were no changes in the concentrations of monocytes, B cells, or Fc receptor-bearing cells when acute and convalescent values were compared. During the convalescent period, a progressive increase in eosinophils was noted. Also, on day 15 but not on day 30 of the convalescent period, an increase was observed in the total leukocyte number due to an increase in granulocytes. There results indicate that in Thai children with dengue hemorrhagic fever, there are major shifts within several component cell subpopulations of the immune system.
对16名患登革出血热的泰国儿童的外周血白细胞进行检测，以确定发病当天以及恢复期第15天和第30天的白细胞组成。每次分离单核细胞，并测定T细胞、B细胞、Fc受体阳性细胞和“裸”细胞的浓度。住院当天，与恢复期的值相比，总淋巴细胞显著增加，主要是由于非典型淋巴细胞的浓度增加。T细胞显著减少，非T、非B、非Fc受体阳性的裸细胞增加。比较急性期和恢复期的值时，单核细胞、B细胞或Fc受体阳性细胞的浓度没有变化。在恢复期，嗜酸性粒细胞逐渐增加。此外，在恢复期第15天而非第30天，由于粒细胞增加，白细胞总数增加。这些结果表明，患登革出血热的泰国儿童免疫系统的几个组成细胞亚群内有重大变化。
