Gilbreath M J, Pavanand K, MacDermott R P, Ussery M, Burke D S, Nimmannitya S, Tulyayon S
J Clin Microbiol. 1983 Apr;17(4):672-6. doi: 10.1128/jcm.17.4.672-676.1983.
Antilymphocyte antibodies were found in 51 of 83 serum specimens from Thai children with dengue hemorrhagic fever (DHF). The lymphocytotoxic activity was complement dependent, and cytotoxicity was detected in the 19S immunoglobulin M-associated serum fractions at a temperature optimum of 15 degrees C. Sera with lymphocytotoxic activity were cytotoxic to autologous as well as allogeneic lymphocytes from patients and healthy adult donors and were directed primarily against B cells, with some T cell cross-reactivity. This study suggests that infection with DHF induces predominately cold-reactive antilymphocyte antibodies in DHF patients that could potentially interact with peripheral blood cells of patients and modulate the humoral immune responses of patients during infection.
在83份来自泰国登革出血热（DHF）患儿的血清样本中，有51份检测到抗淋巴细胞抗体。淋巴细胞毒性活性依赖补体，在19S免疫球蛋白M相关血清组分中于最适温度15℃时检测到细胞毒性。具有淋巴细胞毒性活性的血清对患者自身以及来自患者和健康成年供体的同种异体淋巴细胞均具有细胞毒性，且主要针对B细胞，有一些T细胞交叉反应性。本研究提示，DHF感染在DHF患者中主要诱导冷反应性抗淋巴细胞抗体，这些抗体可能与患者外周血细胞相互作用，并在感染期间调节患者的体液免疫反应。
