Mattern P, Klein F, Pautrizel R, Jongepier-Geerdes Y E
Infect Immun. 1980 Jun;28(3):812-7. doi: 10.1128/iai.28.3.812-817.1980.
Rheumatoid factor (RF)-like substances and heterophil agglutinins (HA) were induced in rabbits by infection with a strain of Trypanosoma equiperdum. Infection with a T. gambiense strain produced HA, but no RF. RFs appeared usually before immunoglobulin G (IgG) levels started to increase. They disappeared spontaneously after 4 to 6 weeks. HA were of the IgM class, appeared within 1 to 2 weeks after infection, and usually remained at high levels afterwards. They could not be absorbed out with lyophilized whole trypanosomes. Therapy suppressed the formation of RF as well as of HA, but IgG complexes as well as antibodies against trypanosomal antigens remained present for considerable periods after the installment of therapy. It is concluded that RFs are not induced by IgG complexes. The results suggest that HA are probably not cross-reacting antibodies induced by trypanosomal antigens.
用一株马媾疫锥虫感染兔子后，可诱导产生类风湿因子（RF）样物质和嗜异性凝集素（HA）。用冈比亚锥虫菌株感染可产生HA，但不产生RF。RF通常在免疫球蛋白G（IgG）水平开始升高之前出现。它们在4至6周后自发消失。HA属于IgM类，在感染后1至2周内出现，之后通常保持在高水平。它们不能被冻干的全锥虫吸收掉。治疗可抑制RF和HA的形成，但在治疗开始后的相当长一段时间内，IgG复合物以及针对锥虫抗原的抗体仍然存在。得出的结论是，RF不是由IgG复合物诱导产生的。结果表明，HA可能不是由锥虫抗原诱导产生的交叉反应抗体。
