Lipton J M, Reinherz E L, Kudisch M, Jackson P L, Schlossman S F, Nathan D G
J Exp Med. 1980 Aug 1;152(2):350-60. doi: 10.1084/jem.152.2.350.
Cell-cell interactions between mature T cells and peripheral blood null cells induce erythropoietin-stimulated differentiation of peripheral blood-derived erythroid progenitors. By the use of complement-fixing cytolytic murine hybridoma and antibody uniquely reactive with mature T lymphocytes, this dependence of immature peripheral blood erythroid burst-forming unit (BFU-E) differentiation upon mature T cells or a T cell conditioned medium is confirmed. By using the same antibody, it is demonstrated that the differentiation of mature bone marrow BFU-E does not require either mature T cells or lymphocyte mitogenic factor. These findings do not preclude the presence in the bone marrow of other cells, perhaps even immature T cells, that influence erythropoietin-dependent erythroid differentiation of mature marrow BFU-E.
成熟T细胞与外周血空细胞之间的细胞间相互作用可诱导促红细胞生成素刺激外周血来源的红系祖细胞分化。通过使用补体固定溶细胞性小鼠杂交瘤以及与成熟T淋巴细胞具有独特反应性的抗体，证实了未成熟外周血红系爆式集落形成单位（BFU-E）的分化依赖于成熟T细胞或T细胞条件培养基。通过使用相同的抗体，证明成熟骨髓BFU-E的分化既不需要成熟T细胞也不需要淋巴细胞促有丝分裂因子。这些发现并不排除骨髓中存在其他细胞，甚至可能是未成熟T细胞，它们会影响成熟骨髓BFU-E的促红细胞生成素依赖性红系分化。
