有被小窝起着分子过滤器的作用。
Coated pits act as molecular filters.
作者信息
Bretscher M S, Thomson J N, Pearse B M
出版信息
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4156-9. doi: 10.1073/pnas.77.7.4156.
Abstract
Two proteins--theta and H63 antigens--are found to be excluded from coated pits on fibroblast plasma membranes. Coated pits thus act as molecular filters, pinching off, into the cell, lipid vesicles containing a limited number of specific receptors but excluding other plasma membrane proteins. This constitutes part of a lipid flow cycle that was proposed earlier to explain the capping of crosslinked surface antigens.
摘要
人们发现两种蛋白质——θ抗原和H63抗原——被排除在成纤维细胞质膜的包被小窝之外。因此，包被小窝起到分子过滤器的作用，将含有有限数量特定受体的脂质小泡 pinched off 进入细胞，同时排除其他质膜蛋白。这构成了脂质流动循环的一部分，该循环是之前为解释交联表面抗原的聚集而提出的。
注
“pinched off”这里可能是“掐断、分离”之类的意思，但结合语境不太好准确翻译，暂保留英文。
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