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PHA诱导的可溶性因子可激活慢性淋巴细胞白血病患者的B细胞。

PHA-induced soluble factor(s) can activate B-cells from patients with chronic lymphatic leukaemia.

作者信息

Robert K H

出版信息

Clin Exp Immunol. 1979 Sep;37(3):517-22.

PMID:315847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537779/
Abstract

Blood lymphocytes from eight patients with chronic lymphatic leukaemia (CLL) were stimulated by phytohaemagglutinin (PHA). The effect was defined as a pronounced increase of 3H-thymidine incorporation, and a concomitant blast transformation of a large portion of surface Ig-positive, E-rosette-forming (E-RFC) negative cells. E-RFC depletion reduced these effects to nearly background levels, and the pooled data strongly suggest that malignant B-lymphocytes in CLL are capable of responding to a PHA-induced T cell factor. A possible use for this factor in characterizing different subpopulations of CLL cells is discussed.

摘要

用植物血凝素（PHA）刺激8例慢性淋巴细胞白血病（CLL）患者的血液淋巴细胞。其效应表现为3H-胸腺嘧啶核苷掺入显著增加，同时大部分表面免疫球蛋白阳性、E-玫瑰花结形成（E-RFC）阴性的细胞发生原始细胞转化。去除E-RFC可使这些效应降低至接近背景水平，汇总数据强烈提示CLL中的恶性B淋巴细胞能够对PHA诱导的T细胞因子作出反应。本文讨论了该因子在鉴定CLL细胞不同亚群方面的可能用途。

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本文引用的文献

1
Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.人类T和B淋巴细胞的表面标志物。I. 大量与绵羊红细胞形成非免疫性玫瑰花结的淋巴细胞。
J Exp Med. 1972 Aug 1;136(2):207-15. doi: 10.1084/jem.136.2.207.
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Functional analysis of B cell heterogeneity.B细胞异质性的功能分析
Transplant Rev. 1975;24:3-40. doi: 10.1111/j.1600-065x.1975.tb00164.x.
3
Receptors for Helix pomatia A haemagglutinin on leukaemic lymphocytes from patients with chronic lymphocytic leukaemia (CLL).慢性淋巴细胞白血病（CLL）患者白血病淋巴细胞上的马蹄螺A血凝素受体
Clin Exp Immunol. 1976 Nov;26(2):196-203.
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Modification of the response of human T lymphocytes to phytomitogens by cocultivation with unresponsive non-T leukocytes.通过与无反应性非T淋巴细胞共培养来改变人T淋巴细胞对植物有丝分裂原的反应。
Scand J Immunol. 1976;5(5):467-77. doi: 10.1111/j.1365-3083.1976.tb00301.x.
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[Lymphocyte in chronic lymphatic leukemia].[慢性淋巴细胞白血病中的淋巴细胞]
Blut. 1975 May;30(5):293-308. doi: 10.1007/BF01633649.
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Further characterization of the circulating cell in chronic lymphocytic leukemia.
Blood. 1976 Aug;48(2):223-34.
7
B-cell activation of peripheral blood lymphocytes from patients with chronic lymphatic leukaemia.慢性淋巴细胞白血病患者外周血淋巴细胞的B细胞活化
Clin Exp Immunol. 1978 Aug;33(2):302-8.
8
Activation of human lymphocyte subpopulations by rabbit anti-human beta2-microglobulin and by lipopolysaccharide.兔抗人β2-微球蛋白和脂多糖对人淋巴细胞亚群的激活作用。
Scand J Immunol. 1976;5(8):891-900. doi: 10.1111/j.1365-3083.1976.tb03039.x.

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