PHA诱导的可溶性因子可激活慢性淋巴细胞白血病患者的B细胞。

PHA-induced soluble factor(s) can activate B-cells from patients with chronic lymphatic leukaemia.

作者信息

Robert K H

出版信息

Clin Exp Immunol. 1979 Sep;37(3):517-22.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537779/

Abstract

Blood lymphocytes from eight patients with chronic lymphatic leukaemia (CLL) were stimulated by phytohaemagglutinin (PHA). The effect was defined as a pronounced increase of 3H-thymidine incorporation, and a concomitant blast transformation of a large portion of surface Ig-positive, E-rosette-forming (E-RFC) negative cells. E-RFC depletion reduced these effects to nearly background levels, and the pooled data strongly suggest that malignant B-lymphocytes in CLL are capable of responding to a PHA-induced T cell factor. A possible use for this factor in characterizing different subpopulations of CLL cells is discussed.

摘要

用植物血凝素（PHA）刺激8例慢性淋巴细胞白血病（CLL）患者的血液淋巴细胞。其效应表现为3H-胸腺嘧啶核苷掺入显著增加，同时大部分表面免疫球蛋白阳性、E-玫瑰花结形成（E-RFC）阴性的细胞发生原始细胞转化。去除E-RFC可使这些效应降低至接近背景水平，汇总数据强烈提示CLL中的恶性B淋巴细胞能够对PHA诱导的T细胞因子作出反应。本文讨论了该因子在鉴定CLL细胞不同亚群方面的可能用途。

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J Exp Med. 1972 Aug 1;136(2):207-15. doi: 10.1084/jem.136.2.207.

2

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3

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