Autio K, Turunen O, Lundqvist C, Schröder J
Clin Exp Immunol. 1978 Nov;34(2):188-92.
The mitogenic activity of protein A (PA), leucoagglutinin (LA) and pokeweed mitogen (PWM) was tested in six cases of chronic lymphatic leukaemia (CLL), and the response to PA and LA in six healthy controls. The effect of foetal calf serum (FCS) and pooled human AB serum in the cultures was tested in two patients. The response to LA in the patients was about one tenth of that in the controls. The response to PA was strong both in patients and in healthy controls. However, in lymphocytes from CLL patients this response was serum-dependent, being very strong with FCS in the culture medium, but absent when the medium contained human AB serum. Lymphocytes from normal controls responded to PA in the presence of AB serum.
在6例慢性淋巴细胞白血病（CLL）患者中检测了蛋白A（PA）、白细胞凝集素（LA）和商陆有丝分裂原（PWM）的促有丝分裂活性，并在6名健康对照者中检测了他们对PA和LA的反应。在两名患者中测试了胎牛血清（FCS）和混合人AB血清在培养物中的作用。患者对LA的反应约为对照者的十分之一。患者和健康对照者对PA的反应都很强。然而，CLL患者淋巴细胞的这种反应依赖于血清，在培养基中加入FCS时反应很强，但当培养基中含有人类AB血清时则无反应。正常对照者的淋巴细胞在AB血清存在的情况下对PA有反应。
