Gupta S, Good R A
Clin Exp Immunol. 1977 Nov;30(2):222-8.
T lymphocytes with receptors for IgM(Tmu) and IgG(Tgamma) were examined in thirty patients with primary immunodeficiency and autoimmune disorders. Six out of twenty-seven patients with primary immunodeficiency had a low proportion of Tmu cells when compared with normal controls. Eight out of twenty-seven patients with primary immunodeficiency had an increased proportion of Tgamma cells. Two out of twenty-seven patients had both a low proportion of Tmu cells and a high proportion of Tgamma cells. The patient studied with severe combined immunodeficiency had a low proportion of both Tmu and Tgamma cells. Patients with Bruton-type agammaglobulinaemia, common variable immunodeficiency, thymoma and immunodeficiency syndrome and selective IgA deficiency demonstrated heterogeneity with regard to alterations in T-cell subpopulations.
对30例原发性免疫缺陷和自身免疫性疾病患者的具有IgM受体的T淋巴细胞（Tmu）和具有IgG受体的T淋巴细胞（Tgamma）进行了检测。与正常对照组相比，27例原发性免疫缺陷患者中有6例Tmu细胞比例较低。27例原发性免疫缺陷患者中有8例Tgamma细胞比例升高。27例患者中有2例Tmu细胞比例低且Tgamma细胞比例高。患有严重联合免疫缺陷的患者Tmu和Tgamma细胞比例均较低。患有布鲁顿型无丙种球蛋白血症、常见变异型免疫缺陷、胸腺瘤和免疫缺陷综合征以及选择性IgA缺乏症的患者在T细胞亚群改变方面表现出异质性。
