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Structures of the DNA adducts formed in mouse liver after administration of the proximate hepatocarcinogen 1'-hydroxyestragole.

作者信息

Phillips D H, Miller J A, Miller E C, Adams B

出版信息

Cancer Res. 1981 Jan;41(1):176-86.

PMID:6969628
Abstract
摘要

相似文献

1
Structures of the DNA adducts formed in mouse liver after administration of the proximate hepatocarcinogen 1'-hydroxyestragole.
Cancer Res. 1981 Jan;41(1):176-86.
2
Major role of hepatic sulfotransferase activity in the metabolic activation, DNA adduct formation, and carcinogenicity of 1'-hydroxy-2',3'-dehydroestragole in infant male C57BL/6J x C3H/HeJ F1 mice.肝脏磺基转移酶活性在1'-羟基-2',3'-脱氢草蒿脑对雄性C57BL/6J×C3H/HeJ F1幼鼠的代谢活化、DNA加合物形成及致癌性中的主要作用
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3
Further characterization of the DNA adducts formed by electrophilic esters of the hepatocarcinogens 1'-hydroxysafrole and 1'-hydroxyestragole in vitro and in mouse liver in vivo, including new adducts at C-8 and N-7 of guanine residues.对肝癌致癌物1'-羟基黄樟素和1'-羟基草蒿脑的亲电酯在体外和小鼠肝脏体内形成的DNA加合物进行进一步表征，包括鸟嘌呤残基C-8和N-7处的新加合物。
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32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice.对用黄樟素、草蒿脑和其他天然存在的链烯基苯处理的动物肝脏中形成的DNA加合物进行³²P后标记分析。I.成年雌性CD-1小鼠。
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Identification and quantitation of hepatic DNA adducts formed in B6C3F1 mice from 1'-hydroxy-2',3'-dehydroestragole: comparison of the adducts detected with the 1'-3H-labelled carcinogen and by 32P-postlabelling.
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Evaluation of human interindividual variation in bioactivation of estragole using physiologically based biokinetic modeling.应用基于生理学的生物动力学模型评价人个体间异戊烯基雌醚生物活化的差异。
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