Meyer O, Gaudreau A, Peltier A P
Rev Rhum Mal Osteoartic. 1980 Oct;47(10):561-8.
The authors studied the correlations between renal histology and specific antinuclear antibodies of soluble nuclear antigens (anti-Sm, anti-RNP, anti-protein) in 44 patients with such auto-antibodies. They were mostly patients with lupus erythematosus (35/44), more rarely mixed collagen disease or Sjögren's disease. The presence of any one of the specific antibodies of nuclear antigens is not associated with any special renal prognosis; thus the presence of anti-RNP does not mean that there are no histological renal lesions. The renal prognosis depends in fact on the presence of anti-ADN native antibodies. Among the other laboratory parameters (rheumatoid factors, complement levels, cryoglobulinemia) only hypocomplementemia seems to be associated with a poor renal prognosis, the presence of rheumatoid factor has perhaps a protective role.
作者研究了44例具有此类自身抗体患者的肾脏组织学与可溶性核抗原特异性抗核抗体（抗Sm、抗RNP、抗蛋白质）之间的相关性。他们大多是红斑狼疮患者（35/44），较少是混合性胶原病或干燥综合征患者。核抗原特异性抗体中的任何一种的存在与任何特殊的肾脏预后均无关联；因此，抗RNP的存在并不意味着没有肾脏组织学病变。实际上，肾脏预后取决于抗双链DNA天然抗体的存在。在其他实验室参数（类风湿因子、补体水平、冷球蛋白血症）中，只有低补体血症似乎与不良的肾脏预后相关，类风湿因子的存在可能具有保护作用。
