采用51铬方法逐日测定乙酰水杨酸诱导的胃肠道出血情况。

Acetylsalicylic acid-induced gastrointestinal bleeding determined by a 51Cr method on a day-to-day basis.

作者信息

Dybdahl J H, Daae L N, Larsen S, Ekeli H, Frislid K, Wiik I, Aanstad L

出版信息

Scand J Gastroenterol. 1980;15(7):887-95. doi: 10.3109/00365528009181547.

Abstract

The daily gastrointestinal blood loss caused by plain and microencapsulated acetylsalicylic acid (ASA) tablets was compared. Fourteen healthy, male volunteers participated in a double-blind, cross-over study, lasting 38 days. Before drug administration a median gastrointestinal bleeding of 0.9 ml/24 h was observed. During oral intake of 1.5 g ASA twice a day for 5 days, an increased faecal blood loss was seen in all volunteers. The increase was significant for both plain and microencapsulated ASA (p less than 0.01). Plain ASA tablets, however, caused a greater faecal blood loss than the microencapsulated tablets (p = 0.05), maximum median levels being 6.2 ml/24 h and 3.9 ml/24 h, respectively. An optimal design of radiochromium studies for determination of drug-induced gastrointestinal blood loss is discussed.

摘要

对普通乙酰水杨酸（ASA）片剂和微囊化ASA片剂引起的每日胃肠道失血量进行了比较。14名健康男性志愿者参与了一项为期38天的双盲交叉研究。在给药前，观察到胃肠道出血中位数为0.9 ml/24小时。在连续5天每天口服1.5 g ASA期间，所有志愿者的粪便失血量均增加。普通ASA和微囊化ASA的增加均具有显著性（p<0.01）。然而，普通ASA片剂引起的粪便失血量比微囊化片剂更大（p = 0.05），最大中位数水平分别为6.2 ml/24小时和3.9 ml/24小时。讨论了用于测定药物诱导的胃肠道失血量的放射性铬研究的优化设计。