Arimori S, Koriyama K, Hiramatsu K, Shimizu Y, Matsumura Y
Tokai J Exp Clin Med. 1980 Oct;5(4):385-98.
Decreases in numbers and functions of SLE T lymphocytes as a form of lymphoreceptopathy were investigated using T lymphocytes and sera obtained from both SLE patients and healthy subjects with respect to the effects of suppressor T cells and Con A induced suppressor factor against antibody formation, changes in the membrane microviscosity and the ultrastructure of membrane associated particles (MAPs) of T lymphocytes. The lymphoreceptopathy of SLE T lymphocytes was induced by decreased microviscosity and abnormalities of distribution, size and density of MAPs on the T lymphocyte membrane which can be modulated by serum factors consisting mainly of IgG as T cell membrane binding antibody and partially of IgM as cytotoxic antibody.
以SLE患者和健康受试者的T淋巴细胞及血清为研究对象，针对抑制性T细胞和刀豆蛋白A诱导的抑制因子对抗体形成的影响、T淋巴细胞膜微黏度变化以及膜相关颗粒（MAPs）超微结构，研究了作为淋巴细胞受体病一种形式的SLE T淋巴细胞数量和功能的下降情况。SLE T淋巴细胞的淋巴细胞受体病是由T淋巴细胞膜微黏度降低以及MAPs在分布、大小和密度上的异常所诱导的，这些异常可由主要作为T细胞膜结合抗体的IgG和部分作为细胞毒性抗体的IgM组成的血清因子进行调节。
