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T淋巴细胞迁移率:抗坏血酸、组胺和复合IgG的缺陷及影响

T lymphocyte mobility: defects and effects of ascorbic acid, histamine and complexed IgG.

作者信息

Smogorzewska E M, Layward L, Soothill J F

出版信息

Clin Exp Immunol. 1981 Jan;43(1):174-9.

Abstract

T lymphocyte mobility is low in patients with low neutrophil mobility. Thymocytes move comparably with normal mature T lymphocytes. Histamine accelerates T lymphocyte mobility in healthy subjects, patients with defective lymphocyte mobility and thymocytes. Ascorbic acid increases lymphocyte mobility of healthy subjects and thymocytes. Inhibition of mobility of T- or Tmu-depleted T lymphocytes by complexed IgG casts doubt on previous reports that the T gamma cells do not move.

摘要

中性粒细胞迁移率低的患者,其T淋巴细胞迁移率也低。胸腺细胞的迁移情况与正常成熟T淋巴细胞相当。组胺可加速健康受试者、淋巴细胞迁移功能缺陷患者及胸腺细胞的T淋巴细胞迁移。抗坏血酸可提高健康受试者及胸腺细胞的淋巴细胞迁移率。复合IgG对T细胞或Tmu缺失的T淋巴细胞迁移的抑制作用,使人对之前关于Tγ细胞不迁移的报道产生怀疑。

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Heterogeneity of locomotion in human T cell subsets.人类T细胞亚群运动的异质性。
Proc Natl Acad Sci U S A. 1978 May;75(5):2392-5. doi: 10.1073/pnas.75.5.2392.

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