中性粒细胞游走原发性和继发性缺陷患者的临床病理表现
Clinicopathological findings in patients with primary and secondary defects of neutrophil mobility.
作者信息
Earhoudi A, Harvey B A, Soothill J F
出版信息
Arch Dis Child. 1978 Aug;53(8):625-30. doi: 10.1136/adc.53.8.625.
Abstract
Twenty-eight patients with defective neutrophil mobility were classified, largely on results of parent values, into primary (17)--mainly Shwachman's syndrome--and probable secondary (11). They presented with frequent infections and/or allergy and these symptoms were essentially similar in both groups. Neutropenia was virtually confined. to the patients with Shwachman's syndrome. Diagnoses associated with secondary neutrophil mobility defects included hydrocephalus with shunt, cystic fibrosis, and immunoglobulin deficiency. The neutrophil mobility of nearly nearly all the patients studied increased when levamisole was added in vitro, but there was no clear evidence of clinical benefit when patients were given the drug.
摘要
28例中性粒细胞游走功能缺陷患者，主要根据其原始数据结果，分为原发性（17例）——主要为施瓦赫曼综合征——和可能的继发性（11例）。他们表现为频繁感染和/或过敏，两组这些症状基本相似。中性粒细胞减少实际上仅限于施瓦赫曼综合征患者。与继发性中性粒细胞游走功能缺陷相关的诊断包括脑积水伴分流、囊性纤维化和免疫球蛋白缺乏。几乎所有研究患者的中性粒细胞游走功能在体外加入左旋咪唑后均增强，但给予患者该药物时，尚无明确的临床获益证据。
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