在AKR小鼠白血病细胞上的两种C型病毒核心多聚蛋白
Two species of type C viral core polyprotein on AKR mouse leukemia cells.
作者信息
Tung J S, Pinter A, Fleissner E
出版信息
J Virol. 1977 Aug;23(2):430-5. doi: 10.1128/JVI.23.2.430-435.1977.
Abstract
Two species of glycosylated type C viral core polyprotein were identified on the surface of AKR spontaneous leukemia cells. One of these cell surface polyproteins was shown by immunoprecipitation to have antigenic determinants of murine leukemia virus p30, p15, p12, and p10; the other had murine leukemia virus p30, p15, and p12, but not p10, determinants. Both species were also expressed on thymocytes from 6-month-old, preleukemic AKR mice.
摘要
在AKR自发性白血病细胞表面鉴定出两种糖基化的C型病毒核心多蛋白。通过免疫沉淀显示，其中一种细胞表面多蛋白具有鼠白血病病毒p30、p15、p12和p10的抗原决定簇；另一种具有鼠白血病病毒p30、p15和p12的抗原决定簇，但不具有p10的抗原决定簇。这两种蛋白在6个月大的白血病前期AKR小鼠的胸腺细胞上也有表达。
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