Magnien E, Dalschaert X, Coppola M
Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Nov;40(5):463-74. doi: 10.1080/09553008114551441.
Protoplasts from a diploid Nicotiana species were used to investigate the effects of gamma-rays and fast neutrons. The damage was assessed by scoring the relative plating efficiencies. The effects of single acute doses, as well as fractionated doses, are described for both qualities of radiation. The dose--r.b.e. relationship, expressing the effectiveness of fast neutrons relative to gamma-rays as a function of dose, appears similar to that of most animal systems, with higher values in the region of lower doses. The fractionation of gamma-ray doses, with sufficiently long time intervals between split doses, allowed a substantial recovery, as known also for X-rays. On the other hand, the fractionation of a fast neutron dose into low single fractions markedly increased the biological effectiveness of the total dose. This could not be explained by cell progression during resting time intervals and necessitated an additional hypothesis, possibly involving other mechanisms in the specific action of low doses of radiation.
来自二倍体烟草属物种的原生质体被用于研究γ射线和快中子的效应。通过对相对平板效率进行评分来评估损伤情况。文中描述了这两种辐射性质的单次急性剂量以及分次剂量的效应。剂量-相对生物效应关系表示快中子相对于γ射线的有效性作为剂量的函数，这一关系似乎与大多数动物系统的情况相似，在较低剂量区域具有更高的值。γ射线剂量的分次给予，在分次剂量之间有足够长的时间间隔时，会出现显著的恢复，这在X射线中也已为人所知。另一方面，将快中子剂量分成分数较低的单次剂量会显著提高总剂量的生物学效应。这无法通过静止时间间隔内的细胞进程来解释，因此需要一个额外的假设，可能涉及低剂量辐射特定作用中的其他机制。
