Pandolfi F, De Rossi G, Semenzato G, Quinti I, Ranucci A, De Sanctis G, Lopez M, Gasparotto G, Aiuti F
Blood. 1982 Apr;59(4):688-95.
Chronic lymphocytic leukemia of T-cell origin (T-CLL), a rare variant of CLL, appears to be a clonal proliferation of mature T cells of one of several subsets. In the cells of 7 T-CLL patients, surface markers (including those reacting with a panel of monoclonal antibodies), functional activities, and electron microscopic morphology were evaluated. The phenotypic patterns of circulating T-CLL cells correspond to those of normal mature T-cell subsets. The cells of three patients demonstrated at least one marker reported to be expressed by suppressor/cytotoxic T cells: those of three patients expressed markers apparently linked with T-helper activity. Cells from one patient appeared to be a heterogeneous proliferation of more than one T-cell subset. These T-CLL cells may also retain some of the functional activity of the normal T subpopulations. Our data indicate that a combination of several tests should be used to characterize the proliferating cells in T-CLL.
T 细胞起源的慢性淋巴细胞白血病（T-CLL）是慢性淋巴细胞白血病的一种罕见变体，似乎是几种亚群之一的成熟 T 细胞的克隆性增殖。对 7 例 T-CLL 患者的细胞进行了表面标志物（包括与一组单克隆抗体反应的标志物）、功能活性和电子显微镜形态学评估。循环 T-CLL 细胞的表型模式与正常成熟 T 细胞亚群的表型模式一致。3 例患者的细胞显示出至少一种据报道由抑制性/细胞毒性 T 细胞表达的标志物；3 例患者的细胞表达了明显与 T 辅助活性相关的标志物。1 例患者的细胞似乎是不止一个 T 细胞亚群的异质性增殖。这些 T-CLL 细胞也可能保留正常 T 亚群的一些功能活性。我们的数据表明，应该使用多种检测方法相结合来表征 T-CLL 中的增殖细胞。
