低剂量率下 Cf-252 中子的生物学效应

Biological effects of Cf-252 neutrons at low dose rates.

作者信息

Feola J M, Nava C A, Maruyama Y

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Jan;41(1):33-46. doi: 10.1080/09553008214550031.

Abstract

The EMT6 tumour of the Balb/c mouse and the LSA ascites lymphoma of the C57BL/YM mouse have been used to study the effects of Cf-252 neutrons at low dose rates. EMT6 and LSA cells were irradiated in vitro in a hypoxic state; EMT6/KY cells were plated after exposure for colony-forming ability assays, while TD50 assays were used to test the tumour-forming ability of LSA cells. EMT6 cells showed r.b.e.n values of 5.3, 4.7, and 3.0 for Cf-252 dose rates of 26.8, 10.2, and 5.2 cGy/hour (= rad/hour), respectively, when compared to Cs-137 irradiations at dose rates of 79.7, 25.7 and 12.1 cGy/hour, respectively. The LSA ascites gave r.b.e.n values of 5.6 and 5.2 at dose rates of 27.0 and 6.94 cGy/hour of Cf-252, when compared to Cs-137 irradiations at 79.6 and 24.9 cGy/hour, respectively. However, changes in r.b.e. values for both systems were entirely dependent on comparison with Cs-137 survival curves.

摘要

已使用Balb/c小鼠的EMT6肿瘤和C57BL/YM小鼠的LSA腹水淋巴瘤来研究低剂量率下Cf-252中子的效应。EMT6和LSA细胞在缺氧状态下进行体外照射；照射后接种EMT6/KY细胞进行集落形成能力测定，同时使用TD50测定法来测试LSA细胞的致瘤能力。与分别以79.7、25.7和12.1 cGy/小时（=拉德/小时）的剂量率进行的Cs-137照射相比，当Cf-252的剂量率分别为26.8、10.2和5.2 cGy/小时（=拉德/小时）时，EMT6细胞的相对生物学效应值（r.b.e.n）分别为5.3、4.7和3.0。与分别以79.6和24.9 cGy/小时进行的Cs-137照射相比，当Cf-252的剂量率为27.0和6.94 cGy/小时时，LSA腹水的相对生物学效应值（r.b.e.n）分别为5.6和5.2。然而，两个系统的相对生物学效应值（r.b.e.）变化完全取决于与Cs-137存活曲线的比较。