Leatham E W, Bath P M, Tooze J A, Camm A J
Department of Cardiological Sciences, St George's Hospital Medical School, London.
Br Heart J. 1995 Jan;73(1):10-3. doi: 10.1136/hrt.73.1.10.
To investigate whether monocyte expression of tissue factor is increased in patients with acute coronary syndromes and chronic stable angina.
Cross sectional study of monocyte tissue factor expression in patients with ischaemic heart disease and control subjects.
Unstable angina and myocardial infarction are associated with enhanced mononuclear cell procoagulant activity. Procoagulant activity of blood monocytes is principally mediated by tissue factor expression. Tissue factor initiates the coagulation cascade and monocyte tissue factor expression may therefore be increased in these syndromes.
Monocyte tissue factor expression was measured cytometrically in whole blood flow using a polyclonal rabbit antihuman tissue factor antibody.
30 patients with acute myocardial infarction, 17 with unstable angina, 13 with chronic stable angina, and 11 normal control subjects.
Increased proportions of monocytes expressing tissue factor (> 2.5%) were found in none of 11 (0%) normal subjects, five 13 (38%) patients with stable angina, 11 of 17 (64%) patients with unstable angina, and 16 of 30 (53%) patients with myocardial infarction (2P = 0.006). Blood from all subjects showed similar monocyte tissue factor expression similar monocyte tissue factor expression (46.1 (15.1)%) after lipopolysaccharide stimulation.
Hypercoagulability associated with acute myocardial infarction, unstable angina, and chronic stable angina may be induced by tissue factor expressed on circulating monocytes.
研究急性冠状动脉综合征和慢性稳定型心绞痛患者单核细胞组织因子的表达是否增加。
对缺血性心脏病患者和对照者的单核细胞组织因子表达进行横断面研究。
不稳定型心绞痛和心肌梗死与单核细胞促凝活性增强有关。血液单核细胞的促凝活性主要由组织因子表达介导。组织因子启动凝血级联反应，因此在这些综合征中单核细胞组织因子表达可能增加。
使用多克隆兔抗人组织因子抗体，通过细胞计数法在全血流中测量单核细胞组织因子表达。
30例急性心肌梗死患者、17例不稳定型心绞痛患者、13例慢性稳定型心绞痛患者和11例正常对照者。
11名（0%）正常受试者中无一例单核细胞表达组织因子的比例增加（>2.5%），13名稳定型心绞痛患者中有5例（38%），17名不稳定型心绞痛患者中有11例（64%），30名心肌梗死患者中有16例（53%）（P=0.006）。所有受试者的血液在脂多糖刺激后显示出相似的单核细胞组织因子表达（46.1（15.1）%）。
急性心肌梗死、不稳定型心绞痛和慢性稳定型心绞痛相关的高凝状态可能由循环单核细胞上表达的组织因子诱导。
