Manthorpe R, Teppo A M, Bendixen G, Wegelius O
Arthritis Rheum. 1982 Jun;25(6):662-7. doi: 10.1002/art.1780250609.
SS-B antigen, purified from rabbit thymus, was used in an indirect enzyme immunoassay to demonstrate the presence of IgG-, IgA-, and IgM-type SS-B antibodies in sera from patients with well-defined and characterized chronic inflammatory connective tissue disease. High levels of antibodies to SS-B were found in patients with primary and secondary Sjögren's syndrome. Patients with Sjögren's syndrome secondary to systemic lupus erythematosus had significantly higher SS-B antibody values than patients with Sjögren's syndrome secondary to rheumatoid arthritis or patients with rheumatoid arthritis or systemic lupus erythematosus, alone. Two patients with rheumatoid arthritis without secondary Sjögren's syndrome also had a markedly elevated level of antibodies to SS-B. Antibodies of all immunoglobulin classes were found, although the highest values were either IgG- or IgM-type. In primary Sjögren's syndrome, antibody values to SS-B were higher in patients with HLA-Dw2 and/or HLA Dw3 than in those with other HLA-Dw types. We conclude that these antigens or specific immune-response genes close to the D region may be important for the development of antibodies to SS-B.
从兔胸腺中纯化的SS - B抗原，用于间接酶免疫测定，以检测明确诊断和特征化的慢性炎症性结缔组织病患者血清中IgG型、IgA型和IgM型SS - B抗体的存在。在原发性和继发性干燥综合征患者中发现了高水平的抗SS - B抗体。系统性红斑狼疮继发的干燥综合征患者的SS - B抗体值显著高于类风湿关节炎继发的干燥综合征患者、单独患有类风湿关节炎或系统性红斑狼疮的患者。两名无继发性干燥综合征的类风湿关节炎患者的抗SS - B抗体水平也明显升高。虽然最高值为IgG型或IgM型，但发现了所有免疫球蛋白类别的抗体。在原发性干燥综合征中，携带HLA - Dw2和/或HLA Dw3的患者的抗SS - B抗体值高于携带其他HLA - Dw类型的患者。我们得出结论，这些抗原或靠近D区域的特异性免疫反应基因可能对抗SS - B抗体的产生很重要。
