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外周血单核细胞和粒细胞在皮肤T细胞淋巴瘤中的作用。

Functions of peripheral-blood monocytes and granulocytes in cutaneous T-cell lymphoma.

作者信息

Hamminga L, Leijh P C, Blussé van oud Alblas A, Van Vloten W A, Van Furth R

出版信息

Br J Dermatol. 1982 Aug;107(2):157-64. doi: 10.1111/j.1365-2133.1982.tb00333.x.

DOI:10.1111/j.1365-2133.1982.tb00333.x
PMID:6980659
Abstract

Granulocyte and monocyte functions (phagocytosis, intracellular killing, chemokinesis and chemotaxis) and the opsonic and chemotactic activity of the serum of twenty-two patients with cutaneous T-cell lymphoma were assessed. Granulocyte functions were within the normal control range in most cases. The monocyte functions showed more variation in the test results; in six out of twenty-two patients intracellular killing of Staphylococcus aureus was depressed and in four out of ten patients a disturbance in monocyte chemotaxis was found. Two patients with a decreased chemotactic response also had an impaired capacity to kill S. aureus. No correlation was found between the cell disturbance and susceptibility to infection, stage of the disease, or clinical course in these patients.

摘要

对22例皮肤T细胞淋巴瘤患者的粒细胞和单核细胞功能(吞噬作用、细胞内杀伤、趋化运动和趋化性)以及血清的调理和趋化活性进行了评估。大多数情况下,粒细胞功能在正常对照范围内。单核细胞功能的测试结果显示出更多差异;22例患者中有6例对金黄色葡萄球菌的细胞内杀伤能力降低,10例患者中有4例发现单核细胞趋化性障碍。两名趋化反应降低的患者对金黄色葡萄球菌的杀伤能力也受损。在这些患者中,未发现细胞功能障碍与感染易感性、疾病分期或临床病程之间存在相关性。

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