大剂量甲氨蝶呤联合亚叶酸钙和长春新碱治疗恶性间皮瘤。

High-dose methotrexate with citrovorum factor and vincristine in the treatment of malignant mesothelioma.

作者信息

Dimitrov N V, Egner J, Balcueva E, Suhrland L G

出版信息

Cancer. 1982 Oct 1;50(7):1245-7. doi: 10.1002/1097-0142(19821001)50:7<1245::aid-cncr2820500704>3.0.co;2-h.

DOI:10.1002/1097-0142(19821001)50:7<1245::aid-cncr2820500704>3.0.co;2-h

Abstract

The incidence of malignant mesothelioma has increased greatly in the last 40 years. Current and recent past exposure to asbestos is expected to substantially increase this incidence. We report nine cases of malignant mesothelioma which temporarily responded to treatment with high-dose methotrexate-citrovorum rescue and vincristine. Further clinical trials of high-dose methotrexate with citrovorum rescue appear indicated in this disease.

摘要

在过去40年中，恶性间皮瘤的发病率大幅上升。目前及近期接触石棉预计会大幅增加这一发病率。我们报告了9例恶性间皮瘤病例，这些病例对大剂量甲氨蝶呤-亚叶酸解救疗法和长春新碱治疗有暂时反应。大剂量甲氨蝶呤联合亚叶酸解救疗法的进一步临床试验似乎适用于这种疾病。