环孢素A对钙离子载体A23187激活淋巴细胞的影响。
Effect of cyclosporin A on lymphocyte activation by the calcium ionophore A23187.
作者信息
Kay J E, Benzie C R, Borghetti A F
出版信息
Immunology. 1983 Nov;50(3):441-6.
Abstract
The activation of pig lymphocytes by the divalent cation ionophore A23187 is more sensitive to inhibition by cyclosporin A than is activation by plant lectins such as concanavalin A. Complete inhibition of A23187-induced activation was seen at a cyclosporin A concentration of 0.3 micrograms/ml. The very early stimulation of nucleoside uptake induced by A23187 was not affected by cyclosporin A, but other early metabolic changes occurring during the first few hours after activation were inhibited.
摘要
与植物凝集素（如伴刀豆球蛋白A）激活猪淋巴细胞相比，二价阳离子载体A23187激活猪淋巴细胞对环孢菌素A的抑制作用更为敏感。在环孢菌素A浓度为0.3微克/毫升时，可观察到A23187诱导的激活作用被完全抑制。A23187诱导的核苷摄取的极早期刺激不受环孢菌素A的影响，但激活后最初几小时内发生的其他早期代谢变化受到抑制。
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