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1
Effect of cyclosporin A on lymphocyte activation by the calcium ionophore A23187.环孢素A对钙离子载体A23187激活淋巴细胞的影响。
Immunology. 1983 Nov;50(3):441-6.
2
Effects of cyclosporin A on the metabolism of unstimulated and mitogen-activated lymphocytes.环孢素A对未刺激及丝裂原激活淋巴细胞代谢的影响。
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3
Inhibition of lymphocyte activation by cyclosporin A: interference with the early activation of the membrane phospholipid metabolism in rabbit lymphocytes stimulated with concanavalin A, anti-rabbit immunoglobulin or the Ca2+ ionophore A 23187.环孢菌素A对淋巴细胞激活的抑制作用：对伴刀豆球蛋白A、抗兔免疫球蛋白或Ca2+离子载体A 23187刺激的兔淋巴细胞膜磷脂代谢早期激活的干扰。
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4
Calcium ion-dependence of the early stimulation of lymphocyte nucleoside transport by phytohaemagglutinin and ionophore A23187 [proceedings].
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Proliferation of human peripheral blood lymphocytes induced by A23187, a streptomyces antibiotic.链霉菌抗生素A23187诱导人外周血淋巴细胞增殖
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10
Cluster formation of canine dendritic cells and lymphocytes is calcium dependent and not inhibited by cyclosporine.
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Cyclosporin A has direct effects on adult neural precursor cells.环孢素 A 对成年神经前体细胞有直接作用。
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Cyclosporine A inhibits Ca2+-dependent stimulation of the Na+/H+ antiport in human T cells.环孢素A抑制人T细胞中Na+/H+逆向转运体的Ca2+依赖性刺激。
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Cyclosporine does not inhibit mitogen-induced inositol phospholipid degradation in mouse lymphocytes.环孢素不抑制丝裂原诱导的小鼠淋巴细胞中肌醇磷脂的降解。
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Formation of hybrid complexes between Ca and the ionophores bromolasalocid (Br-X537A) and A23187.钙与离子载体溴莫拉唑西（Br-X537A）和 A23187 形成的混合配合物。
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Inhibition of proliferation of a murine myeloma cell line and mitogen-stimulated B lymphocytes by the antibiotic amphotericin B (Fungizone).抗生素两性霉素B（制霉菌素）对小鼠骨髓瘤细胞系和丝裂原刺激的B淋巴细胞增殖的抑制作用。
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Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process.环孢素A和地塞米松通过选择性作用于触发过程的不同位点来抑制T细胞反应。
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Effects of cyclosporin A on the metabolism of unstimulated and mitogen-activated lymphocytes.环孢素A对未刺激及丝裂原激活淋巴细胞代谢的影响。
Immunology. 1983 May;49(1):153-60.
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Cyclosporin A blocks receptors for HLA-DR antigens on T cells.环孢素A可阻断T细胞上HLA - DR抗原的受体。
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Ionomycin stimulates T-lymphocytes to grow.离子霉素刺激T淋巴细胞生长。
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Effect of cyclosporin A on human lymphocyte responses in vitro. IV. Production of T cell stimulatory growth factors and development of responsiveness to these growth factors in CsA-treated primary MLR cultures.环孢素A对人淋巴细胞体外反应的影响。IV. CsA处理的原代混合淋巴细胞反应培养物中T细胞刺激生长因子的产生以及对这些生长因子反应性的发展。
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10
Concanavalin A triggers T lymphocytes by directly interacting with their receptors for activation.伴刀豆球蛋白A通过直接与其激活受体相互作用来触发T淋巴细胞。
J Immunol. 1982 Jan;128(1):337-42.

环孢素A对钙离子载体A23187激活淋巴细胞的影响。

Effect of cyclosporin A on lymphocyte activation by the calcium ionophore A23187.

作者信息

Kay J E, Benzie C R, Borghetti A F

出版信息

Immunology. 1983 Nov;50(3):441-6.

PMID:6414942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454254/
Abstract

The activation of pig lymphocytes by the divalent cation ionophore A23187 is more sensitive to inhibition by cyclosporin A than is activation by plant lectins such as concanavalin A. Complete inhibition of A23187-induced activation was seen at a cyclosporin A concentration of 0.3 micrograms/ml. The very early stimulation of nucleoside uptake induced by A23187 was not affected by cyclosporin A, but other early metabolic changes occurring during the first few hours after activation were inhibited.

摘要

与植物凝集素（如伴刀豆球蛋白A）激活猪淋巴细胞相比，二价阳离子载体A23187激活猪淋巴细胞对环孢菌素A的抑制作用更为敏感。在环孢菌素A浓度为0.3微克/毫升时，可观察到A23187诱导的激活作用被完全抑制。A23187诱导的核苷摄取的极早期刺激不受环孢菌素A的影响，但激活后最初几小时内发生的其他早期代谢变化受到抑制。