McLaughlin P J, Zagon I S, White W J
Biol Neonate. 1978;34(1-2):48-54. doi: 10.1159/000241104.
The effects of maternal methadone (5 mg/kg methadone-HCl) administration during gestation and/or lactation on gross body measurements, absolute organ weights, dry weights, and tissue water content were studied in 21-day-old Sprague-Dawley rats. Offsprings perinatally exposed to methadone had significantly lower body weights, crown to rump lengths, tail lengths and head diameters. In contrast to age-control values, absolute organ weights of the adrenals, brain, heart, kidneys, liver, lungs, muscle, and testes were reduced in all drug-treated groups; the spleen, thymus, and ovaries of some methadone groups were also lighter in weight. Organ:body weight ratios revealed fewer significant differences than recorded for absolute weights. Dry weights and tissue water content of the kidneys, liver and muscle were affected in all drug-treated animals; other organs were markedly affected by at least one schedule of methadone administration. These results suggest that perinatal methadone exposure has detrimental effects on preweaning organ and body development that may be of long-term functional consequence to the animal.
在21日龄的斯普拉格-道利大鼠中，研究了孕期和/或哺乳期给予母体美沙酮（5毫克/千克盐酸美沙酮）对大体身体测量、绝对器官重量、干重和组织含水量的影响。围产期暴露于美沙酮的后代体重、冠臀长度、尾巴长度和头部直径显著降低。与年龄对照值相比，所有药物治疗组的肾上腺、脑、心脏、肾脏、肝脏、肺、肌肉和睾丸的绝对器官重量均降低；一些美沙酮组的脾脏、胸腺和卵巢重量也较轻。器官与体重比显示出的显著差异比绝对重量记录的要少。所有药物治疗动物的肾脏、肝脏和肌肉的干重和组织含水量均受到影响；其他器官至少在一种美沙酮给药方案下受到显著影响。这些结果表明，围产期暴露于美沙酮对断奶前器官和身体发育有有害影响，可能对动物产生长期的功能后果。
