Aeromedical considerations of malaria prophylaxis with mefloquine hydrochloride.

Mefloquine hydrochloride (WR 142, 490) is a new investigational drug which is indicated for the prevention and treatment of cloroquine-resistant falciparum malaria thought to be resistant to other drugs. Available information on mefloquine, particularly its potential for "quinine-like" side effects, is of aeromedical importance. These side effects, if present, would be expected to alter performance and body physiology to a degree which would compromise flight safety. There is legitimate concern for mefloquine's safe use in aircrewmen. Mefloquine's potential for "quinine-like" side effects should be evaluated before it is routinely used for suppressive prophylaxis in aircrewmen.