对母源传播抗原的原发性细胞介导的淋巴细胞溶解反应。
Primary cell-mediated lympholysis response to a maternally transmitted antigen.
作者信息
Smith R, Huston D P, Rich R R
出版信息
J Exp Med. 1982 Dec 1;156(6):1866-71. doi: 10.1084/jem.156.6.1866.
Abstract
Mta-specific cytotoxic T lymphocyte (CTL) can be generated in primary cultures of (NZB X B10.D2)F1 spleen cells with H-2-compatible BALB/c stimulator cells. The CTL lyse reciprocal Mta+ (B10.D2 X NZB)F1 as well as H-2-disparate targets, such as B10, B6, and B6-Tlaa; they do not lyse targets from NZB or any F1 hybrid of an NZB mother. The lysis of 51Cr-labeled B10 targets is completely inhibited by unlabeled targets from Mta+ (B10.D2 X NZB)F1, but not from the reciprocal Mta- F1, thus demonstrating H-2-unrestricted lysis of Mta.
摘要
在（NZB×B10.D2）F1脾细胞与H-2相容的BALB/c刺激细胞的原代培养物中可产生Mta特异性细胞毒性T淋巴细胞（CTL）。这些CTL可裂解相互的Mta+（B10.D2×NZB）F1以及H-2不相容的靶细胞，如B10、B6和B6-Tlaa；它们不会裂解来自NZB或任何以NZB为母本的F1杂种的靶细胞。用来自Mta+（B10.D2×NZB）F1的未标记靶细胞可完全抑制51Cr标记的B10靶细胞的裂解，但来自相互的Mta- F1的未标记靶细胞则不能，从而证明了Mta的H-2非限制性裂解。
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